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Dynamic signal encoding in the S. cerevisiae calcium response

Published on October 7, 2013 Updated on May 15, 2020   46 min

A selection of talks on Biochemistry

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Interviewer: Hello, Dr. Dalal, thank you very much for doing this update interview with us today. Where we are going to discuss the changes in the field of dynamic signaling encoding in the Saccharomyces cerevisiae calcium response. We are also going to cover the implications of this new knowledge and where you see the fields headed. So to start, what do we now know on this topic that we did not know at the time of recording your talk in 2013? Dr. Dalal: I think the major thing that we know now that we didn't know then is that, what happens in calcium signaling is not limited to just calcium signaling. What I mean by that is that at the time, the transcriptional regulator CRZ 1 or
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"crazy one" which is responsible for calcium signaling was shown to have these pulses of nuclear localization. And since then we've now, there's been in the field identified at least ten other transcription factors that also pulse. And moreover, all of them have also been characterized in some depth. So now we know that this is not just isolated to calcium signaling, but that this sort of signal encoding occurs all across the yeast genome. And more importantly than that, we also know that orthologs of the CRZ 1 transcriptional regulator, notably NF-AT in mammalian cells also show this sort of pulsatile behavior. And so this sort of dynamic single cell analysis has really enabled us to see how different ways that biological systems can regulate themselves. And it's just, it's not specific to calcium that just happened to be the place where we made the identification first. Interviewer: And so what are the implications of this? Dr. Dalal: I think the implications are that we thought that this, when we first discovered the crazy, the CRZ 1 system, we were really intrigued by the fact that we see this frequency modulated behavior.

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Dynamic signal encoding in the S. cerevisiae calcium response

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