TY - ADVS TI - Dynamic signal encoding in the S. cerevisiae calcium response AU - Dalal, Chiraj A2 - Simpson, Alec PY - 2013 DA - 2013/10/07 N1 - Updated at 2020/05/15 UR - https://hstalks.com/bs/2652/ AB - Calcium and Signaling, Excessive calcium causes cellular stress, Signaling pathways are turned on to combat this stress, In budding yeast, these pathways involve nuclear translocation of transcriptional regulator Crz1, Examination of this regulator shows that nuclear translocation occurs in "bursts", Bursts are quantized and frequency-modulated, Frequency modulation enables proportional expression of downstream target genes, Update interview: Localization pulsing is general, Update interview: Localization pulsing helps regulators control ~1000s of genes at the same time DB - The Biomedical & Life Sciences Collection SN - 2056-452X ID - 3486 PB - Henry Stewart Talks ER -