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Navigable Slide Index

1. Introduction
2. Clinical pharmacogenomics - aims and importance
3. Genetic variability of drug response
4. Genetic polymorphisms in drug metabolism
5. Influence of polymorphisms in DME
6. Practical consequence of genetic variability
7. Genetic-based dose adjustments: an example
8. Future use of pharmacogenetic diagnostics
9. Polymorphic drug metabolizing enzymes
10. Cytochrome P450 enzyme 2D6
11. Variable doxepin kinetics dependent on CYP2D6
12. CYP2D6 genotype based dose adjustment
13. CYP2D6 in mirtazapine kinetics
14. Role of CYP2D6 in antidepressant drug treatment
15. CYP2D6 physiological role
16. Serotonin in platelets after 75 mg doxepin
17. CYP2D6 varients affect antidepressant treatment
18. CYP2D6-based dose adjustments - summary
19. Several polymorphic CYP affect one drug
20. Frequency of mixed CYP genotypes
21. Choosing study volunteers according to genotypes
22. Trimipramine and different CYP genotypes
23. Dose adjustments according to CYP2C219
24. Genotype based dose adjustments - limitations
25. Genotype-phenotype interactions
26. CYP2D6 inter-ethnic differences
27. Clinical validations of dosage adjustments
28. Pharmacogenetics of mood stabilizers
29. Lithium
30. Carbamazepine
31. Types of adverse drug reactions
32. Adverse reactions in antidepressants
33. CYP2D6 genotype in depressed patients with ADR
34. Adverse effects of antipsychotics
35. CYP2D6 and haloperidol clearance
36. Extrapyramidal symptoms and CYP2D6
37. CYP2D6 and tolerability of risperidone
38. Summary
39. Acknowledgements

Topics Covered

• Factors that determine psychiatric importance of genetic variants
• Consequences which arise from genotyping
• Drugs are metabolized via the polymorphic cytochrome P450 enzyme CYP2D6
• Differences in pharmacokinetic parameters for tricyclics, some SSRIs, other antidepressants, typical and some atypical antipsychotic drugs
• Effects on therapeutic efficacy and adverse events
• Indication for genotyping in psychotropic drug treatment
• Future research to close the gap between pharmacogenetic research and clinical practice

Links

Series:

• Psychopharmacogenetics

Categories:

• Genetics & Epigenetics
• Metabolism & Nutrition
• Neuroscience
• Pharmaceutical Sciences

Therapeutic Areas:

• Neurology

Talk Citation

Stingl (formerly Kirchheiner), J. (2007, October 1). Genetic determinants of metabolism: clinical applications in psychiatry [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/264/.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Julia Stingl (formerly Kirchheiner) has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.