Enzymology in drug discovery 1

Published on September 23, 2013   42 min

Other Talks in the Series: Small Molecule Drug Discovery

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Hello and welcome to a series of lectures on entomology and drug discovery. My name is Robert Copeland and I will guide you through this series of two lectures. In the first lecture, we'll talk about the fundamental properties of enzymes, catalysis and what makes these enzymes attractive targets for drug discovery. In the second lecture, we'll talk about the interactions of small molecule reversible inhibitors with enzyme targets that form the basis of much of the pharmacology of small molecule drugs.
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The goals of this series of two lectures or to answer the following questions. What opportunities for Inhibitor interactions exist with an enzyme target? How did these arise from consideration of the reaction mechanism? That will be in large part covered in lecture one. How inhibitors properly evaluated in terms of potency, selectivity and mode of action important questions for the medicinal chemist which will be covered in lecture two, and what information should medicinal chemists and pharmacologists expect from their biology and biochemistry colleagues that will be covered across both of the lectures.