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Printable Handouts
Navigable Slide Index
- Introduction
- Mycobacteria phylogenetic tree
- Slowly growing mycobacteria
- Evolutionary success of M. tuberculosis: genetics
- Genome of M. tuberculosis H37Rv
- M. tuberculosis H37Rv - 4000 genes annotated
- M. tuberculosis H37Rv - zoom-in
- Broad classification of M. tuberculosis genes
- Identifying the essentials genes of M. tuberculosis
- 600 essential genes predicted using TraSH
- High density transposon mutation screens & NGS
- Example for an essential gene - pknB
- M. tub. serine threonine protein kinases (STPK)
- Genomic region pknB - a conserved operon
- PknB is essential for M. tuberculosis
- Identifying virulence factors
- Mycobacterial survival - genetic requirements
- Genes encoding ESX-1 type 7 secretion system
- Other ways to predict genes involved in virulence
- Mycobacterium bovis BCG
- Mycobacterium microti
- Region of difference 1 (RD1)
- RD1 positive vs. RD1 negative proteomes
- BCG-RD1 different colony morphology than control
- The RD1 region codes for ESX-1 (1)
- The RD1 region codes for ESX-1 (2)
- Novel gene nomenclature for T7SS - ESX-1
- Re-integration of RD1 region into BCG
- ESX-1 mediated processes differ in BCG & M. tub.
- M. tuberculosis has 5 ESX/type VII systems
- Comparative genomics within the tubercle bacilli
- Host range of tubercle bacilli
- Comparative genomics identifies RDs
- Sequence conservation of the RD9 junction region
- Comparative genomics identifies TbD1
- TbD1 absent from many M. tuberculosis strains
- Deletion events and the M. tuberculosis complex
- Evolutionary pathway of the tubercle bacilli
- M. tub. variants: presence around the world
- The oldest case of human tuberculosis (in Britain)
- Broad diversity of worldwide M. tuberculosis (1)
- Broad diversity of worldwide M. tuberculosis (2)
- Conclusions and perspectives
- Acknowledgements
Topics Covered
- Mycobacterium tuberculosis
- genome information
- essential genes- virulence genes
- type VII secretion system involved in virulence and host pathogen interaction- genomics and evolution of tuberculosis-causing mycobacteria
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Talk Citation
Brosch, R. (2013, February 28). The genetic structure of Mycobacterium tuberculosis - insights into genome organisation and evolution of the causative agent of tuberculosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 13, 2024, from https://doi.org/10.69645/RSOZ2298.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Roland Brosch has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The genetic structure of Mycobacterium tuberculosis - insights into genome organisation and evolution of the causative agent of tuberculosis
Published on February 28, 2013
34 min
A selection of talks on Infectious Diseases
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