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• 68 min
  1. The mononuclear phagocyte system: tissue resident macrophages - activation and regulation

  • Prof. Emeritus Siamon Gordon
• 25 min
  2. Biosimilars: when value meets cost

  • Prof. Fernando de Mora
• 25 min
  3. Mononuclear phagocytes - origins, fates and functions

  • Prof. Steffen Jung
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  4. Transcription factors in macrophage differentiation

  • Dr. Michael Sieweke
• 44 min
  5. Fetal macrophages

  • Prof. Paul Martin
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  6. The alveolar macrophage

  • Dr. Ronald G. Crystal
• 35 min
  7. Airway macrophages in health and disease

  • Prof. Tracy Hussell
• 65 min
  8. Intestinal macrophages - heterogeneity, origins and functions

  • Prof. Allan Mowat
• 27 min
  9. Osteoclasts: what do they do and how do they do it?

  • Prof. Steven L. Teitelbaum
• 51 min
  10. The biology of Fc receptors and complement receptors

  • Prof. Steven Greenberg
• 71 min
  11. A paradigm shift in the brain-immune relationships: infiltrating macrophages in central nervous system repair

  • Prof. Michal Schwartz
• 38 min
  12. Tumour-associated macrophages

  • Prof. Michele De Palma
  • Dr. Mario Squadrito
• 42 min
  13. The recognition of pathogens by C-type lectins

  • Prof. Gordon D. Brown
• 34 min
  14. Macrophage phagocytosis

  • Prof. Joel Swanson
• 30 min
  15. Macrophage CD36 and atherosclerosis

  • Dr. Maria Febbraio
• 31 min
  16. Toll-Like receptor signaling and the innate immune response

  • Dr. Kate Fitzgerald
• 43 min
  17. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria

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  18. KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions in cellular interactions

  • Prof. Eric Vivier
• 69 min
  19. Triggering receptors expressed on myeloid cells (TREM)

  • Dr. Daniel W. McVicar
• 60 min
  20. Influence of eicosanoid lipid mediators on macrophage innate immune functions

  • Prof. Marc Peters-Golden
• 47 min
  21. Macrophage paired receptor interactions

  • Prof. Neil Barclay
• 45 min
  22. Macrophage heterogeneity in atherosclerosis regression

  • Prof. Edward Fisher
• 35 min
  23. Gaucher disease: from lysosomal storage to immunopathology

  • Prof. Johannes M.F.G. Aerts
• 26 min
  24. Macrophage in asthma

  • Prof. Douglas Robinson
• 51 min
  25. The macrophage mannose receptor

  • Dr. Luisa Martinez-Pomares
• 41 min
  26. Myeloid-derived suppressor cells in cancer

  • Prof. Dmitry Gabrilovich
• 29 min
  27. EGF-TM7 receptors

  • Dr. Jörg Hamann
  • Dr. Hsi-Hsien Lin
• 37 min
  28. Macrophages in helminth infection

  • Prof. Judith Allen
• Archived Lectures *These may not cover the latest advances in the field
• 49 min
  29. Immunosuppressive mechanisms in myeloid cells

  • Prof. Dmitry Gabrilovich

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Speaker's personal background
3. Clinical expression of Gaucher disease (GD)
4. Molecular basis of Gaucher disease
5. Enzyme deficiency & lysosomal lipid accumulation
6. Type 1 Gaucher disease
7. Genetic & phenotypic heterogeneity
8. Discordant monozygotic Gaucher twins
9. Sources of GlcCer substrate
10. Gaucher cells driving visceral pathology
11. Is type 1 GD only a disorder of macrophages?
12. Disease; storage cells; therapeutic correction
13. Therapies for type 1 Gaucher disease
14. Enzyme replacement therapy
15. Disease; storage cells; biomarkers
16. Protein biomarkers
17. Chitotriosidase: a marker for Gaucher disease
18. Gaucher cells as source of chitotriosidase
19. Chitotriosidase: the human macrophage chitinase
20. Plasma chitotriosidase changes upon ERT
21. Use in clinical management of type 1 GD patients
22. Chitotriosidase plasma levels
23. Pitfalls with chitotriosidase measurement
24. Superior substrate for chitotriosidase assay
25. Chitotriosidase deficiency
26. Chemokine CCL18/PARC
27. Elevated CCL18 levels in Gaucher serum
28. Protein composition of Gaucher cells: proteomics
29. Galectin-3: newly discovered protein abnormality
30. Markers of skeletal disease in Gaucher patients
31. MIP-1alpha and MIP-1beta in GD plasma
32. Gaucher cells don't produce MIP-1beta or alpha
33. Plasma MIP-1beta and skeletal disease
34. Potential lipid biomarkers
35. Increased plasma GlcCer and GM3 in type 1 GD
36. Increased plasma GlcSph in type 1 GD
37. Plasma GlcSph correction by ERT
38. Plasma GlcSph and disease manifestations
39. Glucosylsphingosine: a cytotoxic compound
40. Plasma GlcSph: a Gaucher biomarker
41. Other pathologies related to Gaucher disease
42. Skin pathophysiology
43. Brain pathophysiology: different hypotheses
44. Bone disease
45. Osteoporosis in Gaucher disease
46. Metabolic abnormalities
47. Impaired insulin sensitivity
48. Growth retardation
49. Increased risk for cancer
50. Increased risk for parkinsonism
51. Immune system: the missing link?
52. Acknowledgements

Topics Covered

• Gaucher disease
• Clinical manifestations
• Primary defect: gene, enzyme, storage material
• Visceral pathology: organomegaly and haematological complications
• Gaucher cells: lipid-laden macrophages
• Circulating markers for storage cells
• Therapy
• Other pathological aspects of Gaucher disease: bone, brain, body metabolism

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on January 30, 2013

Financial Disclosures

• Prof. Johannes M.F.G. Aerts has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.