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• 52 min
  1. Principles of cytokine-receptor interactions and signal transduction

  • Dr. Xiaoxia Li
• 47 min
  2. Toll-like receptor signalling during infection and inflammation

  • Prof. Luke O'Neill
• 74 min
  3. Cytokines and CD4 T Cells: dance partners at the immunology ball

  • Dr. William E. Paul
• 38 min
  4. The gamma c family of cytokines

  • Dr. Warren J. Leonard
• 29 min
  5. Interleukin-6: back to the future

  • Prof. Tadamitsu Kishimoto
• 59 min
  6. Regulation of the immune response to pathogens 1

  • Prof. Anne O’Garra
• 33 min
  7. Regulation of the immune response to pathogens 2

  • Prof. Anne O’Garra
• 23 min
  8. IL-17 cytokine family and receptors

  • Prof. Chen Dong
  • Dr. Seon Hee Chang
• 40 min
  9. The b common (bc) family of cytokines, receptors and ligands

  • Prof. Angel Lopez
  • Dr. Timothy Hercus
• 29 min
  10. TNF superfamily cytokines and receptors in the healthy and diseased immune system

  • Dr. Richard Siegel
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 49 min
  12. IL-1 as a key inflammatory regulator in autoinflammatory diseases

  • Dr. Raphaela Goldbach-Mansky
• 58 min
  13. Signaling for the interferon family of receptors and ligands and clinical implications

  • Prof. Leonidas Platanias
• 45 min
  14. Interferons as antivirals: translating basic research into clinical application

  • Prof. Eleanor N. Fish
• 49 min
  15. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 22 min
  16. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  17. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 49 min
  18. Receptor identification for alarmins and DAMPs

  • Dr. Joost J. Oppenheim
• 41 min
  19. Assays for cytokines and cytokine assay performance 1

  • Prof. Theresa Whiteside
• 39 min
  20. Assays for cytokines and cytokine assay performance 2

  • Prof. Theresa Whiteside
• 23 min
  21. Interleukin-7 and T cells

  • Dr. Scott Durum
• Archived Lectures *These may not cover the latest advances in the field
• 32 min
  22. Assays for cytokines and cytokine assay standardization

  • Prof. Theresa Whiteside

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Talk outline
3. Gamma C family cytokines
4. Importance of gamma C cytokines
5. Cytokines
6. Type I and type II cytokines
7. Type I cytokines
8. GH/GHR complex
9. IL-2
10. IL-2 receptors
11. IL-2 - IL2R interaction
12. The high affinity IL-2 receptor
13. Two receptor components in gamma C cytokines
14. The expanded "IL-2 family" of cytokines
15. X-linked severe combined immunodeficiency
16. Basis for T, NK, and B-cell defects in XSCID
17. Why share gamma C? (1)
18. Why share gamma C? (2)
19. Why share gamma C? (3)
20. Cytokine pleiotropy and redundancy
21. Cytokine receptor pleiotropy and redundancy
22. IL-2 activates multiple signaling pathways
23. JAK-STAT pathway
24. Pleiotropic use of JAKs
25. Causes of T-B+NK- and T-B+NK+ SCID
26. What is the basis for signaling specificity?
27. Pleiotropic use of STATs
28. Gamma C family cytokine sources - summary
29. Actions of IL-2
30. Therapy related to IL-2
31. Activities of IL-4
32. Activities of IL-7
33. Activities of IL-9
34. Activities of IL-15
35. Pleiotropic actions of IL-21
36. Activities of IL-21
37. Clinical potential of IL-21
38. Cells with receptor chains for gamma C cytokines
39. Summary
40. Acknowledgements

Topics Covered

• The gamma c family of cytokines
• General features of cytokines
• Cytokine and cytokine receptor pleiotropy and redundancy
• The gamma c family of cytokines and its relationship to X-linked severe combined immunodeficiency
• Features of gamma c family cytokines (IL-2, IL-4, IL-9, IL-9, IL-15, and IL-21)
• Clinical potential of gamma c cytokines

Links

Series:

• Cytokines

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on December 18, 2012

Financial Disclosures

• Dr. Warren J. Leonard has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.