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1. Introduction
2. Glycans have various functions
3. Talk outline
4. N-Glycosylation occurs at RER, Golgi apparatus
5. Glycosyltransferases involved branching
6. Major glycosyltransferases and their functions
7. Role of N-glycans in the cell surface receptors
8. N-glycan essential for glucose transporter location
9. Glucose transporter 2(Glut2)
10. Impaired glucose transport in GnT-IVa deficiency
11. Integrin-mediated signaling
12. Aberrant N-glycosilation affects Integrin function
13. The ErbB family and ligands
14. ErbB-mediated signaling pathways
15. Potential N-glycosylation sites of the ErbB family
16. Regulation of ErbB dimerization by N-glycan
17. Diminished PECAM-signaling, ST6Gal I deficiency
18. Role of alpha2,6-sialic acid-PECAM interaction
19. Implications of glycans in disease
20. Chronic obstructive pulmonary disease (COPD)
21. Pathogenesis of COPD
22. Core fucose is a product catalyzed by Fut8
23. Semi-lethality, growth retardation of Fut8 null mice
24. TGF-beta receptor downregulated in Fut8-/- lung
25. Enhanced degrading of ECM, lung emphysema
26. Cigarette smoke decreased FUT8 activity
27. Fut8 heterozygous KO mice and cigarette smoke
28. Take home message
29. Acknowledgements
30. References

Topics Covered

• Review of cell surface glycoprotein receptors
• Glucose transporters 2
• Integrins
• Epidermal growth factor receptor
• Platelet Endothelial adhesion molecules
• Transforming growth factor beta receptor
• the common structure of these receptors
• Production of N-glycans
• N-glycans in disease: diabetes and COPD

Links

Series:

• Glycobiology

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on November 27, 2012

Financial Disclosures

• Prof. Naoyuki Taniguchi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.