• The Basics of Glycan Structure, Biosynthesis, and Function
• 28 min
  1. Use of heparosan polysaccharide to enhance drug delivery

  • Prof. Paul L. DeAngelis
• 31 min
  2. Recognition of 'self' and 'non-self' glycans by carbohydrate-binding proteins: structural and functional aspects

  • Prof. Gerado Vasta
• 49 min
  3. O-GlcNAc, an essential regulator of numerous cellular pathways

  • Dr. Natasha Zachara
• 58 min
  4. Plant cell wall: structure and biosynthesis

  • Prof. Debra Mohnen
  • Dr. Melani A. Atmodjo
• 51 min
  5. GPI-anchored glycoproteins

  • Prof. Michael Ferguson
• 52 min
  6. The role of bacterial carbohydrates in microbe-plant interactions: Rhizobium- legume nitrogen-fixing symbiosis

  • Prof. Russell Carlson
• 51 min
  7. Structure of cell walls in yeast and other fungi

  • Dr. Peter Lipke
• Glycan Regulation and Function in Development and Physiology
• 49 min
  8. Function of carbohydrate recognition by C-type lectins on dendritic cells in “host defence” and “immune homeostasis”

  • Dr. Yvette Van Kooyk
• 23 min
  9. Glycan regulation of receptor functions

  • Prof. Naoyuki Taniguchi
• Glycan Involvement in Disease and Disorders
• 31 min
  10. Congenital disorders of N-glycosylation

  • Prof. Harry Schachter
• 44 min
  11. Glycosylation changes during oncogenesis

  • Prof. Michael Pierce
• Innovative Technologies for Glycoscience and Glycomics
• 70 min
  12. Protein-glycan interactions

  • Prof. James Prestegard
• 41 min
  13. Glycobiology: an untapped source of novel drugs

  • Dr. John Magnani
• 59 min
  14. Development of glyco-biomarkers using glycoproteomics technologies

  • Dr. Hisashi Narimatsu
• 40 min
  15. GlycoBioInformatics

  • Dr. René Ranzinger
• Archived Lectures *These may not cover the latest advances in the field
• 46 min
  16. Glycosyltransferases: structures and mechanisms

  • Prof. Monica Palcic
• 50 min
  17. Roles of glycans in yeast cell walls

  • Dr. Peter Lipke

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. What are GPI membrane anchors?
3. How are proteins bound to membranes?
4. Examples of GPI-anchored proteins (1)
5. Examples of GPI-anchored proteins (2)
6. Examples of GPI-anchored proteins (3)
7. Features of GPI-anchored proteins
8. GPI transamidase
9. GPI-anchored protein biosynthesis (1)
10. GPI-anchored protein biosynthesis (2)
11. GPI-anchored protein biosynthesis (3)
12. GPI-anchored protein biosynthesis (4)
13. GPI-anchored protein biosynthesis (5)
14. GPI-anchored protein biosynthesis (6)
15. Lipid remodeling reactions
16. General structure of GPI anchors
17. Introduction to the African trypanosome
18. Human African Sleeping Sickness
19. Trypanosome TEM & SEM images
20. The trypanosome surface coat (1)
21. The trypanosome surface coat (2)
22. The trypanosome surface coat (3)
23. The trypanosome VSG GPI anchor
24. How the GPI structure was determined
25. Remove contaminants
26. Find some associations
27. Find some more associations
28. Complete the associations with NMR and MS
29. GPI reactions for structure determination
30. Solved GPI structures (1)
31. Solved GPI structures (2)
32. Differences in parasite and host GPI pathways
33. The cell-free system
34. The modified cell-free system
35. The synthesis of GPI substrates and analogues
36. Examples of GPI biosynthesis experiments
37. Features in GPI pathway substrate recognition
38. GlcNAc-PI de-N-acetylase as a drug target
39. Crosslinking of GPI anchored proteins
40. General functions of GPI anchors
41. Lipid rafts
42. Acknowledgments

Topics Covered

• What are GPI membrane anchors and examples of their occurrence
• The biosynthesis of GPI anchors
• The structure of GPI anchors and analytical methods
• Inhibitors of GPI biosynthesis as therapeutic agents
• Biological functions of GPI membrane anchors

Links

Series:

• Glycobiology

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on November 27, 2012

Financial Disclosures

• Prof. Michael Ferguson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.