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Printable Handouts
Navigable Slide Index
- Introduction
- Store operated calcium entry (SOCE)
- Measurement of SOCE activity
- ICRAC
- Whole cell ICRAC amplification
- STIM1 & Orai1
- STIM1 & Orai1 colocalize
- STIM1 & Orai1 in mammals
- Vascular smooth muscle
- The arterial tunics
- Muscle proliferation and migration
- Diseases of smooth muscle dysfunction
- Balloon angioplasty
- Restenosis in the rat model
- Phenotypic switch of the muscle
- Phenotypic switching and vascular disease
- STIM1 & Orai1 in synthetic VSMC
- STIM1 & Orai1 role in mediating SOCE in VSMC
- STIM1 & Orai1 mediate CRAC currents in VSMC
- STIM1 & Orai1: VSMC migration & proliferation
- STIM1 & Orai1 in an animal model
- STIM1 & Orai1 and restenosis in rats (1)
- STIM1 & Orai1 and restenosis in rats (2)
- shRNA against STIM1 & Orai1: in vivo knockdowns
- In vivo knockdowns (1)
- In vivo knockdowns (2)
- In vivo knockdowns (3)
- NFAT nuclear translocation and activity
- Platelet derived growth factor
- Conclusions
- STIM1 & Orai1 as drug targets
- Acknowledgments
Topics Covered
- Store-operated Ca2+ entry (SOCE)
- Measuring SOCE
- The whole-cell current mediated by SOCE, ICRAC
- The molecular players and mechanisms of activation of SOCE
- Vascular Smooth muscle cell (VSMC) remodeling
- VSMC organization and function
- VSMC contribution to vascular disease
- VSMC remodeling in restenosis
- VSMC remodeling and expression of ion channel/transporters
- SOCE and VSMC remodeling
- Role of STIM1 and Orai1 in VSMC SOCE and ICRAC
- STIM1 and Orai1 upregulation in VSMC from injured rat carotid vessels
- Role of STIM1 and Orai1 in driving VSMC remodeling in vivo
- STIM1- and Orai1-mediated SOCE and NFAT activity in VSMC
- STIM1 and Orai1 and SOCE in response to the potent proliferative and migratory agonist, PDGF
Links
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Talk Citation
Trebak, M. (2012, October 31). Store-operated Ca2+ entry and vascular smooth muscle remodeling [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 4, 2024, from https://doi.org/10.69645/XYGI5587.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Mohamed Trebak has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.