• General Strategies in Biomarker Research
• 55 min
  1. The proteomic revolution

  • Dr. Larry Gold
• 39 min
  2. Lipid biomarkers: lipidomics of the macrophage and plasma lipidomes

  • Prof. Edward A. Dennis
• New Tools for Biomarker Research
• 38 min
  3. The future of CNVs: sequence based resolution and links to human disease 1

  • Prof. Evan Eichler
• 31 min
  4. The future of CNVs: sequence based resolution and links to human disease 2

  • Prof. Evan Eichler
• 59 min
  5. Development of glyco-biomarkers using glycoproteomics technologies

  • Dr. Hisashi Narimatsu
• 32 min
  6. Circulating nucleic acids as biomarkers in cancer patients

  • Prof. Klaus Pantel
• Specific Disease Applications
• 28 min
  7. Biomarkers in breast cancer

  • Prof. Joe Duffy
• 71 min
  8. Bacterial biomarkers

  • Dr. Christiane Honisch
• 32 min
  9. Diabetes biomarkers

  • Prof. Naveed Sattar
• 60 min
  10. Gene networks, brain networks: understanding schizophrenia

  • Dr. Daniel Weinberger
• 29 min
  11. Biomarkers for Huntington's disease - promises and challenges

  • Prof. Sarah Tabrizi
• 31 min
  12. Update on fluid biomarkers for neurodegenerative diseases

  • Prof. Henrik Zetterberg
• 31 min
  13. Biomarkers in osteoarthritis

  • Dr. Ali Mobasheri
• Biomarkers in Drug Discovery and Delivery
• 31 min
  14. Pharmacogenomics: emphasis on clinical drug development

  • Dr. Amelia Warner
• 25 min
  15. Biomarkers in drug development: potential use and challenges

  • Dr. Abdel-Bassett Halim
• 41 min
  16. Patient stratification for drug treatment in oncology and other diseases

  • Dr. Tim Harris
• Biomarkers in development, nutrition, and health
• 50 min
  17. Building genetic and environmental marker models to predict exceptional survival

  • Prof. Thomas Perls
• 29 min
  18. Ethnic differences in nutrition

  • Prof. Jose Ordovas
• 55 min
  19. Non-invasive prenatal diagnostics

  • Prof. Y. M. Dennis Lo
• 44 min
  20. Epigenetic biomarkers in cancer

  • Prof. Bob Brown
• Archived Lectures *These may not cover the latest advances in the field
• 23 min
  21. Biomarkers for Alzheimer's disease

  • Prof. Henrik Zetterberg

Printable Handouts

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Navigable Slide Index

1. Introduction
2. AIST
3. Biological functions of glycans
4. Glycoproteome is the future
5. Glycoproteomics
6. Glycans are clothes for cells (proteins)
7. Variety of monosaccharide
8. N-glycans and O-glycans
9. Human ABO blood antigens
10. Three essentials of glycoscience
11. Glycogene project (GG project)
12. The strategy of cloning for glycogene
13. GG project (2001-2004)
14. Glycogene family cloned and analyzed to date
15. Structural glycomics project (SG project)
16. Complexity of glycan structures
17. Glycan synthesizer
18. Examples for glycan synthesizer performance
19. Methods for glycan structure analysis
20. Multistage tandem mass spectrometry
21. Multi-stage tandem mass spectrometry example
22. Glycogene expression profiling
23. Evanescent-field fluorescence-assisted scanner
24. IGOT LC/MS method
25. Our technology for analyzing glycans
26. Medical glycomics project (MG project)
27. Functions of glycans
28. Glyco-biomarkers for liver fibrosis and cancer
29. The development of glycoprotein biomarker
30. Glycans as serum markers for cancer
31. Glycans methods for cancer seromarkers
32. AGP as a liver fibrosis marker
33. How to succeed in biomarker development?
34. Pathology of liver fibrosis
35. The prevalence of HCV infection
36. Disease severity in HCV infected patients
37. Issue in gold standard procedure "liver biopsy"
38. Issues in current non-invasive system
39. Our motivation
40. Lectin microarray system
41. Fibrosis-related fucosylation in AGP
42. Serum AGP method
43. Differential glycan profiling
44. Lectin as diagnostic tool for liver cirrhosis
45. Transfer to automatic assay system
46. Multi-cohort study in Japan (2009-2010)
47. Comparison of diagnostic performance
48. Biomarkers of cancer
49. Useful biomarkers for diagnosis (1)
50. Useful biomarkers for diagnosis (2)
51. Development of bile duct cancer marker
52. Development of glycan profiling method
53. Marker targeting for tissue sections
54. Diagnostic by MY.1E12 antibody and WFA lectin
55. Novel glyco-biomarker for cholangiocarcinoma
56. WFA-MY.1E12 sandwich ELISA (bile)
57. Specific glycoprotein marker
58. Development of glyco-biomarker
59. Conclusions
60. Construction of glycan-related database

Topics Covered

• Overview of glycans
• Developing the technologies used in glycoscience
• Examples of successful glycobiomarker development

Links

Series:

• Biomarkers
• Glycobiology

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice

Talk Citation

Publication History

• Published on October 11, 2012

Financial Disclosures

• Dr. Hisashi Narimatsu, Grant/Research Support (Principal Investigator): Research grants since 2000 to 2011 every year funded by the government (New Energy and Industrial Technology Development Organization; NEDO) ; Constructions of Libraries of Human Genes Participating in Glycosylation (April 2001-March 2004, Glycogene: NEDO GG project) ; Development of Methodologies and Databases for Structural Glycoproteomics (April 2003-February 2—6, Structural Glycomics: NEDO SG project) ; Developing Technology for Implementing Sugar Chain Functions (April 2006-February 2011, Medical Glycomics: NEDO MG project) ; Research grants since 2007 to present every year funded by the government (ministry of Education, Culture, Sports, Science and Technology (MEXT) Integrated database project).