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Printable Handouts
Navigable Slide Index
- Introduction
- Pathophysiology of COPD & Emphysema
- Lung with COPD
- Carl-Bertil Laurell
- Alpha 1 antitrypsin deficiency
- Antitrypsin deficiency and emphysema lungs 3D
- The alpha 1 antitrypsin protein
- Alpha 1 antitrypsin and elastase
- The elastase
- Elastase and emphysema
- Elastase and other symptoms
- Beat frequency and elastase
- Effects of neutrophil elastase
- Augmentation in AATD
- Augmentation therapy
- Anti inflammatory effects
- Testing emphysema progression
- Location of emphysema
- Emphysema in patients without AATD
- Emphysema with normal lung function
- Alternative approach for assessing emphysema
- The complexity of neutrophil biology
- An inflammatory cell in connective tissue (1)
- An inflammatory cell in connective tissue (2)
- Processes of neutrophil movement
- Cell movement towards signal
- Elastase concentration in azurophil granules
- Elastase concentration change
- Quantum proteolytic events of neutrophils
- Destructive potential of neutrophils
- Chemotaxis of neutrophils
- Neutrophil adherence and migration
- Neutrophils and COPD
- Monitoring neutrophil elastase activity in vivo
- Neutrophil mechanism
- Fibrinogen cleavage point for elastase
- A-alpha360 and elastase inhibitors
- COPD and A-alpha360
- PET scanning and FDG labeling
- Role of proteinases in emphysema
- The other neutrophil serine proteinases
- The smoking mouse
- Alveoli in smokers vs. non smokers
- MMP-12 KO mouse
- MMP-12 KO and neutrophils
- Neutrophil elastase KO mouse
- Enzyme interactions
- TNF alpha and MMP-12 KO mice
- TNF and inflammation
- No connective tissue damage
- A different pathway
- A short summary
- Effects of TNF alpha polymorphisms
- The roles of MMPs
- The process diagram
- Summary
Topics Covered
- Pathophysiology of COPD and Emphysema
- Carl-Bertil Laurell
- Alpha 1 antitrypsin deficiency
- Effects of neutrophil elastase
- Augmentation therapy
- Anti inflammatory effects
- Testing emphysema progression
- Emphysema with normal lung function
- Alternative approach for assessing emphysema
- The complexity of neutrophil biology
- Processes of neutrophil movement
- Elastase concentration change
- Quantum proteolytic events of neutrophils
- Destructive potential of neutrophils
- Chemotaxis
- Neutrophils and COPD
- Monitoring neutrophil elastase activity in vivo
- Elastase inhibitors
- Role of proteinases in emphysema
- The other neutrophil serine proteinases
- The smoking mouse
- Alveoli in smokers vs. non smokers
- Effects of TNF alpha polymorphisms
- The roles of MMPs
Links
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Talk Citation
Stockley, R. (2012, September 13). Protease-antiprotease balance [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 8, 2024, from https://doi.org/10.69645/OXWA8501.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Robert Stockley has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.