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1. Introduction
2. Lecture topics
3. Stem cell - definition
4. Stem cell - asymmetric and symmetric division
5. Stem cell - clonogenicity
6. Stem cells - embryonic or adult
7. What's an embryonic stem cell
8. ES cells - derivation of genetically modified mice
9. ES cells develop normally after reintroduction
10. What's an adult stem cell
11. The difference between adult stem cells and ES
12. Extrinsic and intrinsic renewal factors - mouse ES
13. Extrinsic and intrinsic renewal factors - human ES
14. What's immortality
15. The bus theory
16. Stem cells are potentially immortal and dangerous
17. Why is immortality dangerous
18. Why does an immortal organism die
19. Non-immortal organism
20. Normal cells have a restricted capacity to divide
21. How is programmed cell death advantageous
22. First strategy for generating an organism
23. Second strategy for generating an organism
24. The difference between the two strategies
25. Being mortal protects from cancer
26. Other causes for cellular death
27. Apoptosis
28. Apoptosis - extrinsic and intrinsic pathways
29. Telomere shortening (1)
30. Telomeres are the ends of chromosomes
31. Telomeres - T loops
32. DNA replication
33. Telomere shortening (2)
34. Stem cells overcome telomere shortening
35. TERT expression reverses senescence
36. The impact of regenerative medicine
37. Regenerative medicine - perspectives
38. Ways that regenerative medicine can affect us
39. Adult stem cells in clinical trials
40. Regenerative medicine can raise the lifespan
41. Hurdles of ES-derived regenerative medicine
42. Efficacy of regenerative medicine - studies
43. Immune rejection
44. Safety - tumorigenicity
45. Safety - teratomas
46. Additional safety provided by cell engineering
47. Regulatory acceptance
48. Conclusion

Topics Covered

• What is a stem cell?
• Properties of stem cells
• Adult and embryonic stem cells
• What is immortality?
• Why do we die?
• Mechanisms of programmed cell death
• Mutation
• Connection between tumour protection and ageing
• Impact of regenerative medicine
• Impact of stem cells on lifespan
• Average and maximum lifespan

Links

Series:

• Stem Cells and Regenerative Medicine

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007
• Updated on August 25, 2009

Financial Disclosures

• Dr. Jim McWhir has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.