• View the Talks
• 50 min
  1. Where the thoughts dwell: history of neuroscience and introduction into neuroglia

  • Prof. Alexei Verkhratsky
• 35 min
  2. Astrocytes: definition, appearance and general physiology 1

  • Prof. Alexei Verkhratsky
• 30 min
  3. Astrocytes: definition, appearance and general physiology 2

  • Prof. Alexei Verkhratsky
• 39 min
  4. Glial calcium signalling

  • Prof. Alexei Verkhratsky
• 33 min
  5. Astroglial calcium signalling: what it could tell us

  • Prof. Dmitri Rusakov
• 42 min
  6. Neuronal-glial chemical transmission mediated by glutamate and ATP

  • Prof. Alexei Verkhratsky
• 27 min
  7. Energy and amino acid neurotransmitter metabolism in astrocytes

  • Prof. Helle Waagepetersen
• 49 min
  8. Mechanisms of glutamate release from astrocytes

  • Prof. Vladimir Parpura
• 37 min
  9. Cannabinoid type 1 receptors in astrocytes

  • Prof. Giovanni Marsicano
• 34 min
  10. Neuronal-glial anatomical plasticity in the hypothalamus

  • Dr. Stéphane H.R. Oliet
• 25 min
  11. General physiology of oligodendrocytes

  • Prof. Arthur M. Butt
• 35 min
  12. Neuropathology of microglia and oligodendrocytes

  • Prof. Arthur M. Butt
• 38 min
  13. Oligodendroglia/MCT1 are an unexpected contributor to CNS toxicity/neurodegeneration

  • Prof. Jeffrey D. Rothstein
• 41 min
  14. Physiology and pathophysiology of microglia

  • Prof. Dr. Uwe-Karsten Hanisch
• 39 min
  15. Properties of regulated exocytosis in astrocytes

  • Prof. Robert Zorec
• 49 min
  16. Exocytosis and gliocrine astroglia

  • Prof. Robert Zorec
• 37 min
  17. Noradrenergic hypothesis of neurodegeneration and astroglia

  • Prof. Robert Zorec
• 45 min
  18. Principles of astrogliopathology: from reactivity to atrophy and degeneration

  • Prof. Alexei Verkhratsky
• 23 min
  19. Regulation of synaptic plasticity by astroglia

  • Prof. Dmitri Rusakov
• 48 min
  20. Enteric glia: the glue of the enteric nervous system

  • Dr. Keith A. Sharkey
• 38 min
  21. Purinergic neuron-to-glia signaling in the enteric nervous system

  • Dr. Brian D. Gulbransen
• 43 min
  22. Astrocytes and Alexander disease: the first - but not last - primary astrocyte disease

  • Prof. Albee Messing
• 45 min
  23. Vesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons

  • Prof. Vladimir Parpura
• 43 min
  24. The impact of astrocyte mitochondrial ATP production on neuroprotection after stroke

  • Prof. James Lechleiter
• 33 min
  25. Hepatic encephalopathy in cirrhosis: a disorder of glial-neuronal signalling

  • Prof. Roger F. Butterworth
• 33 min
  26. Hepatic encephalopathy in acute liver failure: a primary neurogliopathy

  • Prof. Roger F. Butterworth
• 37 min
  27. Bi-directional communication at the neurovascular unit: implications for neuronal function

  • Prof. Jessica A. Filosa
• 51 min
  28. Astrocyte reactivity

  • Prof. Michael Sofroniew
• 36 min
  29. Roles of microglia in the healthy brain

  • Dr. Marie-Ève Tremblay
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  30. Astroglia in neuropathology

  • Prof. Alexei Verkhratsky
• 44 min
  31. Cell biology and physiology of astroglia

  • Prof. Alexei Verkhratsky
• 29 min
  32. General physiology of oligodendrocytes and Schwann cells

  • Prof. Arthur M. Butt

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Microglia: a short definition
3. Microglia: resident innate immune cells of CNS
4. Discovery and detection
5. Discovery, detection / functional interpretation (1)
6. Discovery, detection / functional interpretation (2)
7. Approaches to the study of microglia
8. Manipulating and monitoring microglial activities
9. Developmental origin and functions
10. Microglia as macrophage-like cells
11. Origin and lineage
12. Developmental contributions of malfunction (1)
13. Developmental contributions of malfunction (2)
14. Developmental contributions of malfunction (3)
15. The concept of resting microglia
16. Resting or active: dormant or functional
17. Tissue surveillance and synaptic nursing
18. Immunologically silent disposal of myelin
19. The concept of microglial activation
20. Immediate response to homeostatic disturbance
21. The concept of detrimental microglia
22. Microglial activation simply follows a stereotype
23. Microglial activation in CNS pathologies
24. Harmful microglial engagement is recognized
25. Activation signals and response diversity
26. Microglia as active sensors
27. Activity-controlling factors (1)
28. Activity-controlling factors (2)
29. Control via ON and OFF signals
30. Microglial response versatility
31. Macrophages and microglia
32. Signals and response modifiers
33. Elements of the microglial response repertoire (1)
34. Elements of the microglial response repertoire (2)
35. Response dynamics
36. Microglia activation: not a monophasic response
37. Microglia activation: deescalation / termination
38. Contributions in and to CNS pathologies
39. Phenotypes associated with phagocytosis
40. Effects associated with phagocytosis
41. Microglial neuropathology in Alzheimer's disease
42. Microglia in neurodegenerative diseases
43. A uniform population throughout the CNS or not?
44. Conclusion and outlook
45. Questions regarding roles in health and disease
46. Thank you

Topics Covered

• Physiology and pathophysiology of microglia
• Microglia
• resident innate immune cells of the CNS
• Approaches to the study of microglia
• Developmental origin and functions
• Developmental contributions and consequences of malfunction
• The concept of 'resting' microglia
• functions in the healthy adult CNS
• Tissue surveillance and synaptic nursing as house-keeping duties
• The concept of microglial 'activation'
• transformation to distinct activity states
• The concept of detrimental microglia
• Activation signals and response diversity
• Macrophages and microglia: diversity in response behaviour
• Elements of the microglial response repertoire
• Response dynamics
• Microglial phenotypes associated with phagocytosis
• Contributions of microglia in neurodegenerative diseases

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on July 15, 2012

Financial Disclosures

• Prof. Dr. Uwe-Karsten Hanisch has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.