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Navigable Slide Index

1. Introduction
2. Genetics influence traits
3. What is a quantitative trait?
4. Quantitative and multifactorial inheritance
5. Some history
6. Some more history
7. Basic biometric model (1)
8. Basic biometric model (2)
9. Basic biometric model (3)
10. Identity states
11. Identity coefficients
12. Kinship coefficients
13. Covariances for relatives (1)
14. Covariances for relatives (2)
15. Polygenic model (1)
16. Polygenic model (2)
17. Add environment
18. Modeling environment/error
19. Household effects models
20. Variance component models
21. Statistical process
22. A gene x environment model
23. Why? how?
24. G x E model, mean
25. G x E model, variance
26. The San Antonio family heart study
27. The data
28. The questions
29. The results, mean
30. Gene ontology analysis
31. The results, heritability
32. GO BP results poly G x S
33. GO-BP graph for sig poly G x S
34. QTL mapping uses genotype data
35. Genotyping
36. QTL mapping
37. Multivariate model
38. SAFADS example
39. Insulin Resistance Syndrome (IRS)
40. Four trait heritability analysis
41. QTL mapping process (1)
42. QTL mapping process (2)
43. FSI, BMI, leptin and DBP (1)
44. FSI, BMI, leptin and DBP (2)
45. Thanks
46. References

Topics Covered

• Basic Biometric Model: single locus model, identity states and coefficients, Covariances for relatives, polygenic model
• Modeling environment/error
• Gene by environment interaction model and example
• QTL mapping model
• Multivariate model and example

Links

Series:

• Introduction to Human Genetics

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on May 22, 2012

Financial Disclosures

• Dr. Lara Bauman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.