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• 68 min
  1. The mononuclear phagocyte system: tissue resident macrophages - activation and regulation

  • Prof. Emeritus Siamon Gordon
• 25 min
  2. Biosimilars: when value meets cost

  • Prof. Fernando de Mora
• 25 min
  3. Mononuclear phagocytes - origins, fates and functions

  • Prof. Steffen Jung
• 39 min
  4. Transcription factors in macrophage differentiation

  • Dr. Michael Sieweke
• 44 min
  5. Fetal macrophages

  • Prof. Paul Martin
• 44 min
  6. The alveolar macrophage

  • Dr. Ronald G. Crystal
• 35 min
  7. Airway macrophages in health and disease

  • Prof. Tracy Hussell
• 65 min
  8. Intestinal macrophages - heterogeneity, origins and functions

  • Prof. Allan Mowat
• 27 min
  9. Osteoclasts: what do they do and how do they do it?

  • Prof. Steven L. Teitelbaum
• 51 min
  10. The biology of Fc receptors and complement receptors

  • Prof. Steven Greenberg
• 71 min
  11. A paradigm shift in the brain-immune relationships: infiltrating macrophages in central nervous system repair

  • Prof. Michal Schwartz
• 38 min
  12. Tumour-associated macrophages

  • Prof. Michele De Palma
  • Dr. Mario Squadrito
• 42 min
  13. The recognition of pathogens by C-type lectins

  • Prof. Gordon D. Brown
• 34 min
  14. Macrophage phagocytosis

  • Prof. Joel Swanson
• 30 min
  15. Macrophage CD36 and atherosclerosis

  • Dr. Maria Febbraio
• 31 min
  16. Toll-Like receptor signaling and the innate immune response

  • Dr. Kate Fitzgerald
• 43 min
  17. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria

  • Prof. Ricardo Gazzinelli
• 34 min
  18. KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions in cellular interactions

  • Prof. Eric Vivier
• 69 min
  19. Triggering receptors expressed on myeloid cells (TREM)

  • Dr. Daniel W. McVicar
• 60 min
  20. Influence of eicosanoid lipid mediators on macrophage innate immune functions

  • Prof. Marc Peters-Golden
• 47 min
  21. Macrophage paired receptor interactions

  • Prof. Neil Barclay
• 45 min
  22. Macrophage heterogeneity in atherosclerosis regression

  • Prof. Edward Fisher
• 35 min
  23. Gaucher disease: from lysosomal storage to immunopathology

  • Prof. Johannes M.F.G. Aerts
• 26 min
  24. Macrophage in asthma

  • Prof. Douglas Robinson
• 51 min
  25. The macrophage mannose receptor

  • Dr. Luisa Martinez-Pomares
• 41 min
  26. Myeloid-derived suppressor cells in cancer

  • Prof. Dmitry Gabrilovich
• 29 min
  27. EGF-TM7 receptors

  • Dr. Jörg Hamann
  • Dr. Hsi-Hsien Lin
• 37 min
  28. Macrophages in helminth infection

  • Prof. Judith Allen
• Archived Lectures *These may not cover the latest advances in the field
• 49 min
  29. Immunosuppressive mechanisms in myeloid cells

  • Prof. Dmitry Gabrilovich

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Generation of the F4/80 mAb for macrophages
3. F4/80 pan-macrophage marker
4. F4/80 antigen revealed it as a 7-TM receptor
5. EGF-TM7-R: novel type of heptahelical receptor
6. GRAFS classification of GPCRs
7. Human adhesion GPCRs
8. Evolution
9. Expression
10. Exp. restricted to eosinophilic granulocytes
11. Structure
12. Autocatalytic proteolysis of EMR3
13. Homo-, hetero-dimerization of adhesion-GPCRs
14. Complement regulator CD55 is a ligand of CD97
15. EMR2 and CD97 bind chondroitin sulfate B
16. CD97 has several cellular ligands
17. CD97 antibodies affect granulocyte accumulation
18. Granulopoietic activity in CD55 and CD97 KO mice
19. CD97 overexpression strengthens cell junctions
20. F4/80 required for peripheral tolerance
21. EMR2, priming neutrophil migration and activation
22. EMR2 signaling
23. EGF-TM7 receptors at a glance
24. Outstanding questions
25. Acknowledgments

Topics Covered

• F4/80 is a marker for mouse macrophages
• The EGF-TM7 receptors EMR1 (F4/80), EMR2, EMR3, EMR4 and CD97 belong to the adhesion class of GPCRs
• Evolution, expression and structure of EGF-TM7 receptors
• EGF-TM7 receptors bind cell- and matrix-associated ligands
• Role of EGF-TM7 receptors in immunity

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 8, 2012

Financial Disclosures

• Dr. Jörg Hamann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Dr. Hsi-Hsien Lin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.