• Clinical Introduction
• 49 min
  1. Frontotemporal dementia

  • Prof. Bruce Miller
• 57 min
  2. Parkinson disease

  • Prof. Stanley Fahn
• 35 min
  3. Atypical parkinsonian syndromes

  • Dr. David Burn
• 40 min
  4. Huntington's disease

  • Prof. Roger Barker
• Neuroimaging
• 22 min
  5. Molecular brain imaging (PET) in diseases with dementia

  • Prof. Karl Herholz
• Pathology, Genetic and Molecular Aspects (1)
• 42 min
  6. A molecular understanding of Alzheimer's disease

  • Prof. John Hardy
• 33 min
  7. Neuropathology of neurodegenerative disorders

  • Prof. Jillian Kril
• 52 min
  8. The role of MAPT (Tau) in neurodegenerative disease: one bullet with many triggers

  • Dr. Michael Hutton
• 12 min
  9. Ubiquitination and Alzheimer related disorders

  • Prof. John Mayer
• Pathology, Genetic and Molecular Aspects (2)
• 46 min
  10. The molecular biology of Huntington's disease

  • Prof. David C. Rubinsztein
• 46 min
  11. Metals, oxidative stress and neurodegeneration

  • Prof. Ashley Bush
• Latest Developments in the Field
• 46 min
  12. Animal models of tauopathy

  • Prof. David Westaway
• 61 min
  13. Parkinson's disease and transplants

  • Prof. Roger Barker
• Archived Lectures *These may not cover the latest advances in the field
• 29 min
  14. Neuropathology of neurodegenerative disorders

  • Prof. Jillian Kril
• 36 min
  15. Motor neurone disease: molecular basis

  • Prof. Kevin Talbot
• 51 min
  16. Alzheimer's disease (AD)

  • Prof. John Hodges
• 53 min
  17. Frontotemporal dementia syndromes

  • Prof. John Hodges
• 38 min
  18. Motor neurone disease: clinical aspects

  • Prof. Kevin Talbot
• 26 min
  19. Neuro-imaging in dementia: using MRI in routine work-up

  • Prof. Philip Scheltens
• 53 min
  20. Prion diseases

  • Prof. Pierluigi Gambetti
• 38 min
  21. Mitochondrial disorders and neurodegeneration

  • Prof. Anthony Schapira
• 21 min
  22. Neurodegenerative disease: expression levels of normal sequence pathogenic proteins contribute to risk of disease

  • Prof. John Hardy
• 44 min
  23. Mutations in parkinsonian syndromes

  • Dr. Andrew Singleton
• 42 min
  24. Experimental therapies in Alzheimer's disease: the development and use of mouse models

  • Prof. David Westaway
• 32 min
  25. Frontotemporal dementia

  • Prof. Bruce Miller

Printable Handouts

PDF

Navigable Slide Index

1. Intro slide
2. Human prion diseases - classification
3. Prion disease - animals
4. Outline
5. Prion protein (PrP) - hamster
6. Prion protein - normal processing
7. Prion protein - membrane association
8. Normal Prp and PrP(C) 3D-structure
9. Proposed biological functions of normal PrP
10. Pathogenesis of prion diseases
11. PrP(C) and PrP(Sc)/PrP(res) 3D-structure
12. Possible mechanism of PrP propagation
13. PrP propagation in familial forms
14. PrP propagation in acquired form
15. Pathogenetic hypotheses
16. Prion protein (PrP) - hamster
17. Immunoblotting of PrP(C) and PrP(Sc)
18. Immunoblot analysis (case 1 brain biopsy)
19. Human prion diseases - inherited
20. Human PrP - pathogenic mutations/polymorphisms
21. Human prion diseases - sporadic
22. Variants of sCJD
23. Human PrP gene - codon 129 polymorphism
24. Immunoblotting of PrP(C) and PrP(Sc)
25. Classification of sporadic CJD - 300 subjects
26. Codon 129 alleles and PrP(Sc) types
27. Classification of sporadic prion diseases
28. Microscopic view of cerebral cortex
29. sCJDMV2 - only sCJD subtype with kuru plaques
30. PrP immunostain - cerebral cortex
31. 14-3-3 test sensitivity and PrP(Sc) type/phenotype
32. Human prion diseases - acquired by infection
33. Iatrogenic CJDs
34. BSE and vCJD epidemics
35. Variant CJD (1)
36. Variant CJD (2)
37. Variant CJD - "fluorid plaque"
38. PrP immunostain - variant/sporadic CJD
39. The problem of CWD in the USA
40. Prion diseases - treatment
41. Prion research collaborators

Topics Covered

• Normal function of prion protein
• Prion diseases
• Mechanism of propagation of PrP
• Propagation in acquired and familial forms
• Pathogenic hypothesis
• Human pathogenic mutation and polymorphisms
• Laboratory methods
• Epidemiology
• Sporadic prion diseases
• New variant CJD
• Treatment of prion disease

Links

Series:

• Neurodegenerative Diseases

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Pierluigi Gambetti has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.