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1. Introduction
2. The mononuclear phagocyte system
3. Outline of presentation
4. The hematopoietic system
5. Mononuclear phagocyte origins
6. Mouse monocyte subsets
7. Human monocyte subsets
8. Inflammatory and patrolling monocytes
9. Monocyte origins
10. Monocyte origins - mixed BM chimeras (1)
11. Monocyte origins - mixed BM chimeras (2)
12. Conclusion I: Mononuclear phagocyte origins
13. Monocyte fates
14. Conditional mononuclear phagocyte ablation
15. Monocytes reconstitute macrophages
16. MDPs, not monocytes yield splenic cDCs
17. Hierarchy of MDP, monocytes and cDCs
18. Conclusion II: Mononuclear phagocyte origins
19. Gastrointestinal tract
20. Intestinal macrophages
21. The CX(3)CR1/L1 reporter animals (1)
22. The CX(3)CR1/L1 reporter animals (2)
23. Lamina propria mononuclear phagocytes (1)
24. Lamina propria mononuclear phagocytes (2)
25. Migratory DCs and resident macrophages
26. Steady state vs. inflammation
27. Inflammation recruits a novel CX(3)CR1int subset
28. CX(3)CR1int infiltrate is monocyte-derived
29. CX(3)CR1int infiltrate requires CCR2
30. CX(3)CR1int infiltrate promotes inflammation
31. Expression analysis of monocyte progeny
32. CX(3)CR1int respond to bacterial products (1)
33. CX(3)CR1int respond to bacterial products (2)
34. Conclusion
35. Acknowledgments

Topics Covered

• Distinct development of macrophages and dendritic cells
• Distinct functions of dendritic cells and macrophages in the maintenance of gut homeostasis
• The role of inflammatory monocyte infiltrates in gut inflammation

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 8, 2012

Financial Disclosures

• Prof. Steffen Jung has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.