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• 42 min
  1. Historic introduction to innate immunity

  • Prof. Heiko Herwald
  • Prof. Arne Egesten
• 52 min
  2. Evolution of innate immunity

  • Prof. Jim Kaufman
• 25 min
  3. The phagocytic synapse in distinguishing particulate and soluble stimuli

  • Prof. David Underhill
• 23 min
  4. How bacterial pathogens avoid phagocyte killing

  • Dr. Thomas Areschoug
• 43 min
  5. Origin of myeloid cells

  • Prof. Frederick A. Geissmann
• 67 min
  6. Dendritic cells

  • Prof. Muriel Moser
• 38 min
  7. Eosinophil biology and disorders associated with eosinophilia

  • Dr. Thomas B. Nutman
• 60 min
  8. CD1d-restricted NKT cells: regulators of inflammation and autoimmunity

  • Prof. Steven A. Porcelli
• 50 min
  9. Innate-like B cells

  • Prof. John F. Kearney
• 58 min
  10. Cytoplasmic innate immune sensors

  • Prof. Seth Masters
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 28 min
  12. The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome

  • Prof. Robert Wilkinson
  • Prof. Graeme Meintjes
• 37 min
  13. Antimicrobial peptides in the innate immune system of the lung

  • Prof. Dr. Pieter S. Hiemstra
• 49 min
  14. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 45 min
  15. Heat shock proteins and their role in the immune regulation of inflammation

  • Prof. Willem Van Eden
• 42 min
  16. Tissue damage control confers host tolerance to infection

  • Dr. Miguel P. Soares
• 22 min
  17. Autophagy as a barrier to infection

  • Prof. Michele Swanson
• 42 min
  18. Innate immunity in the intestine in health and disease

  • Prof. Kevin Maloy
• 51 min
  19. Dendritic cells and the eye: their role in the ocular immune response

  • Prof. John V. Forrester
• 26 min
  20. Mononuclear phagocytes and HIV infection

  • Dr. Guido Poli
• 41 min
  21. Th17 cells and innate immunity

  • Prof. Mihai Netea
• 37 min
  22. Epigenetic regulation of innate immunity

  • Dr. Osamu Takeuchi
• 66 min
  23. Intracellular DNA sensing pathways

  • Prof. Veit Hornung
• 52 min
  24. Physiology of innate immunity

  • Prof. Keith W. Kelley
• 49 min
  25. Innate immunity in the genitourinary tract: genetics of susceptibility to disease or asymptomatic carriage

  • Prof. Catharina Svanborg
• 32 min
  26. Regulation of type 2 immunity by basophils

  • Prof. David Voehringer
• Archived Lectures *These may not cover the latest advances in the field
• 53 min
  27. TLRs, NLRs, DAMPs and PAMPs

  • Prof. Luke O'Neill

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Outline of the presentation
3. Type 1 vs. Type 2 immunity
4. Type 2 immunity - a double-edged sword
5. Development of a type 2 immune response
6. Discovery of innate type 2 effector cells
7. Basophils, mast cells and eosinophils
8. Developmental relationship
9. Detection of basophils by CD49b/IgE staining
10. Nippostrongylus brasiliensis infection
11. N. brasiliensis infected lung
12. N. brasiliensis infected small intestine
13. Analysis of basophil turnover in vivo
14. Activating receptors on basophils
15. Activation of basophils by IgE
16. Cytokine instruction of basophils
17. Basophil effector functions
18. Generation & analysis of basophil-deficient mice
19. Mast cell protease 8 is expressed in basophils
20. Deletion of basophils in Mcpt8Cre mice
21. Mast cells are not deleted in Mcpt8Cre mice
22. Effector function of basophils
23. Are basophils required for Th2 polarization?
24. DCs or basophils for Th2 polarization? (1)
25. Generation of DC-deficient mice
26. DCs or basophils for Th2 polarization? (2)
27. DCs are required for Th2 polarization
28. Role of innate IL-4 for Th2 polarization
29. Innate IL-4/IL-13 regulates Th2 accumulation
30. Basophils in anaphylactic responses
31. IgG1-mediated systemic anaphylaxis
32. Basophils aren't required for anaphylaxis
33. Basophils in chronic allergic inflammation of skin
34. Basophils are required for allergic inflammation
35. Basophil response against helminths and ticks
36. Primary response to N. brasiliensis
37. Expulsion kinetics of N. brasiliensis
38. Protective immunity against N. brasiliensis
39. Basophils during secondary infection
40. Protective immunity against ticks
41. Summary
42. Acknowledgements

Topics Covered

• Relationship of basophils to mast cells and eosinophils
• Development and activation of basophils
• Basophil-deficient mice
• Role of basophils and dendritic cells in Th2 polarization
• Anaphylaxis and allergic skin inflammation
• Basophil response to helminths and ticks

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on April 3, 2012

Financial Disclosures

• Prof. David Voehringer has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.