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1. Intro slide
2. What is ubiquitin?
3. The ubiquitin proteasome system (UPS)
4. Nobel Prize for ubiquitin
5. Slices of normal brain and Alzheimer brain
6. The ubiquitin pathway & neurodegenerative disease
7. Cortical Lewy body contain ubiquitylated proteins
8. Ubiquitylated proteins in Lewy neurites
9. Dementia with Lewy bodies
10. Ubiquitylated proteins in Alzheimer's disease
11. Dystrophic neurites contain ubiquitylated proteins
12. Protein degradation is crucial for synaptic functions
13. Mutations in PARKIN cause juvenile PD
14. The UPS and the ageing brain
15. Gene expression response to protein aggregates
16. Mitogen-activated protein kinase 3
17. Mitogen-activated protein kinase 5
18. Expression of MEK5 in aggregate producing cells
19. Mitogen activated protein kinase pathways
20. p62/MEK5/ERK5 and Alzheimer's disease
21. p62/MEK5/ERK5 and dementia with Lewy bodies
22. p62/MEK5/ERK5 and granulovacuolar degeneration
23. Model: neurofibrillary tangles & p62/MEK5/ERK5
24. Model: Lewy bodies & p62/MEK5/ERK5
25. p62-MEK5-ERK5-MEF2 & neurodegeneration
26. The UPS & neurodegeneration
27. Clinical implications of the findings

Topics Covered

• Alzheimer's disease and dementia with Lewy bodies
• Ubiquitin and the ubiquitin pathway of intracellular proteolysis
• Ubiquitin immunocytochemistry in understanding chronic neurodegenerative disease
• Ubiquitin and the discovery of dementia with Lewy bodies
• Importance of ubiquitin for normal brain functions
• Ubiquitin and Parkinson's disease
• Intraneuronal protein aggregation and neurodegenerative disease
• Experimental demonstration of generic gene expression changes in response to protein aggregates
• Expression of the mitogen activated protein kinase (MEK5)
• ERK5 kinase module in Alzheimer's disease and dementia with Lewy bodies
• Ubiquitin-p62-MEK5/ERK5 pathway of neuronal survival in Alzheimer related disorders
• Diagnostic and therapeutic importance of ubiquitin/kinase mediated neuronal survival and anti-apoptotic pathways

Links

Series:

• Neurodegenerative Diseases

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. John Mayer has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.