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- Overview of Chaperone Networks
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1. Mapping the molecular chaperone interaction network in yeast
- Prof. Walid A. Houry
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2. The interaction network of the GroEL chaperonin
- Prof. Dr. F. Ulrich Hartl
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3. Human heat shock protein families
- Prof. Herman Kampinga
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4. Extracellular proteostasis: an emerging field
- Prof. Mark Wilson
- Proteasome Networks
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6. Biogenesis of the eukaryotic proteasome
- Prof. Mark Hochstrasser
- Understanding Intrinsically Disordered Proteins in Protein Homeostasis
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7. Intrinsically unstructured proteins: regulation and disease
- Dr. M. Madan Babu
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8. The roles of intrinsic disorder in protein interaction networks
- Prof. Vladimir N. Uversky
- Gene Regulatory Networks and their Role in Protein Homeostasis
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10. Structure, evolution and dynamics of gene regulatory networks
- Dr. M. Madan Babu
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12. Protein-protein interaction networks
- Prof. Peter Csermely
- Protein Homeostasis in the Endoplasmic Reticulum
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13. Role of calnexin and calreticulin in protein homeostasis within the endoplasmic reticulum
- Prof. David B. Williams
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14. The unfolded protein response
- Prof. Kazutoshi Mori
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15. Role of ER stress in cystic fibrosis airway inflammation
- Dr. Carla Maria Pedrosa Ribeiro
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16. The recognition of misfolded glycoproteins in the endoplasmic reticulum
- Dr. David Y. Thomas
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17. Chaperone systems of the endoplasmic reticulum
- Prof. Linda M. Hendershot
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18. The ERAD network
- Prof. Daniel Hebert
- Protein Homeostasis in the Mitochondria
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19. Protein homeostasis in mitochondria: AAA+ chaperones & proteases
- Dr. David A. Dougan
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21. Mitochondrial chaperonin Hsp60: locations, functions and pathology
- Prof. Francesco Cappello
- Prof. Alberto J. L. Macario
- Protein Homeostasis in the Nucleus
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22. Nuclear protein quality control degradation
- Dr. Richard G. Gardner
- Protein Homeostasis in Aging Disease
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23. Protein homeostasis during ageing: C. elegans as a model organism
- Prof. Nektarios Tavernarakis
- Protein Homeostasis in Neurodegeneration
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24. Endoplasmic reticulum stress in neurodegenerative diseases
- Prof. Claudio Soto
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25. Roles for Hsp40 molecular chaperones in protein misfolding disease
- Prof. Douglas M. Cyr
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26. Protein folding in vivo
- Prof. James Bardwell
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27. Protein degradation and defense against neurodegenerative disease 1
- Prof. Alfred Goldberg
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28. Protein degradation and defense against neurodegenerative disease 2
- Prof. Alfred Goldberg
Printable Handouts
Navigable Slide Index
- Introduction
- Neurodegenerative disease (1)
- Neurodegenerative disease (2)
- Neurodegenerative disease (3)
- What causes neurodegenerative diseases?
- Misfolded aggregates deposited in the brain
- Role of protein aggregates in disease
- Research strategy
- Prion diseases
- Two conformations of the prion protein
- Brain alterations in prion diseases
- Experimental scrapie model in mice
- Sequence of events in scrapie pathogenesis
- ERp57 upregulation
- ERp57 and PrPSc correlation in the brain
- Upregulation of other ER chaperones
- ER-stress and UPR in human CJD
- The UPR pathway
- XBP-1 conditional KO did not affect prion disease
- PrP interaction with ER chaperones in brain
- PrPSc induces neuronal death in vitro
- PrPSc induces ER-stress in vitro
- Prion infection sensitizes cells to ER-stress
- Calcium release comes from the ER
- Hypothesis: Prion formation leads to ER stress
- Calcineurin properties
- Signaling pathways
- Calcineurin is implicated in PrPSc toxicity
- A novel treatment for prion diseases
- Treatment improves symptoms (behavior)
- Treatment increases animal survival
- FK506 effect on calcineurin and its targets
- Treatment decreases neuronal death
- Treatment decreases neurodegeneration
- Conclusions
- Acknowledgment
- Former lab members
Topics Covered
- Neurodegenerative disease
- Misfolded aggregates deposited in the brain
- Research strategy
- Prion diseases
- Two conformations of the prion protein
- Experimental scrapie model in mice
- Upregulation of ER chaperones
- ER-stress and UPR in human CJD
- PrP interaction with ER chaperones in brain
- PrPSc induction of ER-stress and neuronal death
- Calcineurin properties
- A novel treatment for prion diseases
Links
Series:
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Therapeutic Areas:
Talk Citation
Soto, C. (2012, February 2). Endoplasmic reticulum stress in neurodegenerative diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 21, 2025, from https://doi.org/10.69645/KWGE4872.Export Citation (RIS)
Publication History
- Published on February 2, 2012
Financial Disclosures
- Prof. Claudio Soto has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.