Registration for a live webinar on 'Innate immunity, inflammation and cancer' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Heat shock genes and proteins discovery
- Heat shock elements and transcription factor 1
- Conditions for activation of HSF-1
- 5 different heat shock protein families
- Some families are nor HSF-1 regulated
- HSPs are molecular chaperones
- HSPs and folding of nascent proteins
- Heat-induced HSP up-regulation
- HSP70 and toxicity protection
- HSPs and mutant proteins
- HSPs: expansion and functional diversification
- Interaction between different HSP families
- HSP70 machines
- Functional specificity via different HSP70s
- Functional specificity via different NEFs
- Functional specificity via different DNAJs
- Functional classification of DNAJ proteins
- Promiscuous client binding in DNAJ proteins
- Ydj1 and Sis1/DNAJB1 generally promote refolding
- DNAJB2 directs clients to degradation
- Selective client binding
- DNAJs without client binding for tethering HSP70
- DNAJC2
- Functional specificity beyond DNAJs
- The HSP70 machine and folding diseases
- PolyQ diseases
- Recognizing HSPs in polyQ disease
- DNAJB6/8 suppressors of poly-Q aggregation
- DNAJB6/8 protect against poly-Q toxicity
- Deletion of SSF-SST region of DNAJB8
- DNAJB6 / DNAJB8 interact with HDACs
- HDAC4 is required for DNAJB6/8 function
- DNAJB8 acetylation
- C-terminal lysines involved in activity of DNAJB8
- DNAJB6 prevents polyQ aggregation in vitro
- DNAJB6/8 prevent polyQ aggregation in cells
- A model of prevention of polyQ aggregation
- HSPB expansion and functional diversification
- HSPB alpha-crystalline domain
- Human HSPB family
- Refolding vs. polyQ aggregation
- Canonical mechanism of refolding
- Non-canonical mechanism of refolding
- Summary
- Acknowledgements
- References
Topics Covered
- Heat shock proteins
- Regulation and chaperone activity
- Several protein families with many different members
- DNAJ family
- Regulation of differentiation of HSP machines to drive client specificity and differential client processing
- Involvement in folding, proteasomal degradation, autophagy
- Potent suppressors of protein deposit diseases, e.g. CAG repeat diseases
Talk Citation
Kampinga, H. (2012, February 2). Human heat shock protein families [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/2212/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Herman Kampinga has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.