• Clinical Introduction
• 49 min
  1. Frontotemporal dementia

  • Prof. Bruce Miller
• 57 min
  2. Parkinson disease

  • Prof. Stanley Fahn
• 35 min
  3. Atypical parkinsonian syndromes

  • Dr. David Burn
• 40 min
  4. Huntington's disease

  • Prof. Roger Barker
• Neuroimaging
• 22 min
  5. Molecular brain imaging (PET) in diseases with dementia

  • Prof. Karl Herholz
• Pathology, Genetic and Molecular Aspects (1)
• 42 min
  6. A molecular understanding of Alzheimer's disease

  • Prof. John Hardy
• 33 min
  7. Neuropathology of neurodegenerative disorders

  • Prof. Jillian Kril
• 52 min
  8. The role of MAPT (Tau) in neurodegenerative disease: one bullet with many triggers

  • Dr. Michael Hutton
• 12 min
  9. Ubiquitination and Alzheimer related disorders

  • Prof. John Mayer
• Pathology, Genetic and Molecular Aspects (2)
• 46 min
  10. The molecular biology of Huntington's disease

  • Prof. David C. Rubinsztein
• 46 min
  11. Metals, oxidative stress and neurodegeneration

  • Prof. Ashley Bush
• Latest Developments in the Field
• 46 min
  12. Animal models of tauopathy

  • Prof. David Westaway
• 61 min
  13. Parkinson's disease and transplants

  • Prof. Roger Barker
• Archived Lectures *These may not cover the latest advances in the field
• 29 min
  14. Neuropathology of neurodegenerative disorders

  • Prof. Jillian Kril
• 36 min
  15. Motor neurone disease: molecular basis

  • Prof. Kevin Talbot
• 51 min
  16. Alzheimer's disease (AD)

  • Prof. John Hodges
• 53 min
  17. Frontotemporal dementia syndromes

  • Prof. John Hodges
• 38 min
  18. Motor neurone disease: clinical aspects

  • Prof. Kevin Talbot
• 26 min
  19. Neuro-imaging in dementia: using MRI in routine work-up

  • Prof. Philip Scheltens
• 53 min
  20. Prion diseases

  • Prof. Pierluigi Gambetti
• 38 min
  21. Mitochondrial disorders and neurodegeneration

  • Prof. Anthony Schapira
• 21 min
  22. Neurodegenerative disease: expression levels of normal sequence pathogenic proteins contribute to risk of disease

  • Prof. John Hardy
• 44 min
  23. Mutations in parkinsonian syndromes

  • Dr. Andrew Singleton
• 42 min
  24. Experimental therapies in Alzheimer's disease: the development and use of mouse models

  • Prof. David Westaway
• 32 min
  25. Frontotemporal dementia

  • Prof. Bruce Miller

Printable Handouts

PDF

Navigable Slide Index

1. Intro slide
2. Outline
3. A brief history (1)
4. A brief history (2)
5. A brief history (3)
6. FTD/FTLD classification (1)
7. FTD: overlaps
8. FTD/FTLD classification (2)
9. Causes of late onset dementia
10. Causes of early onset dementia
11. Levels of classification in FTD
12. Frontal (behavioural) variant FTD (fvFTD)
13. Typical fvFTD case: J.W. (1)
14. Typical fvFTD case: J.W. (2)
15. Typical fvFTD case: J.W. (3)
16. Typical fvFTD case: J.W. (4)
17. Typical fvFTD case: J.W. (5)
18. Typical fvFTD case: J.W. (6)
19. Neuropsychology in fvFTD
20. Theory of mind (ToM)
21. Performance on ToM and physical cartoons
22. Emotion judgement
23. Atrophy in fvFTD: orbitofrontal and medial cortex
24. Semantic dementia (SD)
25. Typical SD case: D.V. (1)
26. Typical SD case: D.V. (2)
27. Typical SD case: D.V. (3)
28. Perirhinal cortex: a key region?
29. VBM correlation with SD
30. Brain basis of concept knowledge?
31. Laterality
32. Word-picture matching: faces vs. animals
33. Progressive Non-Fluent Aphasia (PNFA) (1)
34. Progressive Non-Fluent Aphasia (PNFA) (2)
35. Distribution of atrophy: SD vs. PNFA
36. FTD genetics: tau mutations
37. FTD genetics: non-tau
38. Pathology of FTD: histological subtypes
39. Relationship between pathology/clinical syndrome
40. Pathological basis of SD
41. Histopathology in SD
42. Survival from symptom onset
43. Management

Topics Covered

• Clinical spectrum FTD
• Frontal or behavioural variant
• Semantic dementia
• Progressive non-fluent aphasia
• Disease overlap
• Genetic factors
• Epidemiological facts
• Neuropsychological methods and imaging diagnostics
• Pathological groupings of FTD
• Tau positive inclusions cases including Pick's disease, familial tauopathies and corticobasal degeneration
• Ubiquitin positive inclusions cases
• Multidisciplinary management of FTD

Links

Series:

• Neurodegenerative Diseases

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. John Hodges has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.