• Epidemiology and Risk Factors
• 41 min
  1. The changing prevalence of asthma

  • Dr. Deborah Jarvis
• 29 min
  2. Recent advances in asthma genetics

  • Prof. Miriam Moffatt
• 35 min
  3. Asthma: an epidemic caused by epigenetics?

  • Prof. David Schwartz
• 30 min
  4. Role of the microbiota in asthma

  • Prof. B. Brett Finlay
• 32 min
  5. Diet and asthma

  • Prof. Lewis Smith
• 43 min
  6. Obesity and asthma

  • Prof. Anne Dixon
• 35 min
  7. Occupational asthma: management beyond the textbooks

  • Prof. Paul Cullinan
• Clinical Phenotypes
• 42 min
  8. The origins of asthma

  • Prof. Peter Sly
• 46 min
  9. Pre-school wheeze

  • Prof. Andrew Bush
• 50 min
  10. Updates on the management of difficult asthma in school-aged children

  • Prof. Andrew Bush
• 24 min
  11. Smoking asthmatics

  • Prof. Neil Thomson
• 27 min
  12. Aspirin exacerbated respiratory disease

  • Prof. Chris Corrigan
• Mechanisms of Asthma
• 48 min
  13. Advances in asthma: airway inflammation

  • Prof. William Busse
• 48 min
  14. The role of mast cells in asthma

  • Prof. Peter Bradding
• 67 min
  15. Dendritic cells in asthma

  • Prof. Bart Lambrecht
• 30 min
  16. The airway smooth muscle in asthma

  • Prof. Judith Black
• 49 min
  17. Role of virus infection in asthma 1

  • Prof. Sebastian Johnston
• 27 min
  18. Role of virus infection in asthma 2

  • Prof. Sebastian Johnston
• 51 min
  19. Severe asthma: characterisation, mechanisms & treatment

  • Prof. Fan Chung
• 46 min
  20. Steroid resistance in asthma: mechanisms and potential therapies

  • Prof. Ian Adcock
• 26 min
  21. Macrophage in asthma

  • Prof. Douglas Robinson
• Diagnosis of Asthma
• 70 min
  22. Physiology of asthma and involvement of small airways

  • Prof. Charles G. Irvin
• 27 min
  23. Induced sputum in asthma

  • Prof. Antonio Spanevello
• 61 min
  24. Advances in asthma: the role of exhaled nitric oxide in the assessment and management of asthma

  • Prof. Robin Taylor
• Therapy and Management
• 41 min
  25. Pulmonary drug delivery

  • Prof. Anthony J. Hickey
• 32 min
  26. The management of chronic asthma

  • Prof. Mark Fitzgerald
• 21 min
  27. Inhaled corticosteroids and beta2-agonists

  • Dr. Omar S. Usmani
• 20 min
  28. Management of "difficult asthma"

  • Prof. Elisabeth Bel
• 47 min
  29. Management of acute exacerbations of asthma

  • Dr. Chris Fanta
• 34 min
  30. Non-pharmacological treatments for asthma

  • Prof. Neil Thomson
• 45 min
  31. Asthma: beyond the prescription

  • Prof. Martyn Partridge
• 45 min
  32. New drugs for asthma

  • Prof. Peter Barnes
• 24 min
  33. Anti-IgE therapy for asthma

  • Dr. Andrew Menzies-Gow
• Archived Lectures *These may not cover the latest advances in the field
• 45 min
  34. New drugs for asthma

  • Prof. Peter Barnes
• 35 min
  35. Asthma phenotypes in children

  • Prof. Andrew Bush
• 40 min
  36. Steroid resistance in asthma: mechanisms and potential therapies

  • Prof. Ian Adcock
• 42 min
  37. Severe asthma in children

  • Prof. Andrew Bush

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Asthma background (1)
3. Asthma background (2)
4. Finding disease genes - candidate gene
5. Candidate gene studies
6. Finding disease genes - positional cloning
7. Positional cloned asthma genes
8. Epithelium and asthma genes
9. Over 300 sequenced genomes
10. Finding points to intervene
11. Genome wide association studies for asthma
12. GWAS - asthma
13. Childhood versus adult asthma
14. Chromosome 17q21 and EGEA
15. Global gene expression
16. GWAS: expression of immune response genes
17. ORMDL3 and affymetrix gene expression data
18. ORMDL3: possible functions?
19. Affymetrix vs. Illumina gene expression data
20. Gabriel genetics
21. QC for samples
22. PCA: population structure
23. Results from 36 studies
24. Childhood onset vs. adult onset asthma
25. Association with IgE vs. association with asthma
26. Asthma SNPs and disease risk
27. Conclusions so far
28. Function of 'new asthma genes' - IL33 and IL18
29. Function of 'new asthma genes' - SMAD3, IL2RB
30. Unattributed heritability
31. Asthma and infection
32. Microbial fauna in the body
33. 1% of bacteria may be cultured
34. Sequence detection of bacteria
35. Adults: bronchial brushings
36. Children: bronchial lavage
37. The transnational asthma genetics consortium
38. Still much to do!
39. Growing field - summary
40. Acknowledgments

Topics Covered

• Incidence of asthma
• Environment and genetic causes
• Disease identification prior to completion of sequencing of the human genome
• Genome Wide Association Study (GWAS)
• Omic technologies including global gene expression
• GABRIEL and Asthma susceptibility genes identified by GWAS
• Asthma and infection
• 16S rRNA and metagenomics
• What next

Links

Series:

• Advances in Asthma

Categories:

• Clinical Practice
• Genetics & Epigenetics
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on December 29, 2011

Financial Disclosures

• Prof. Miriam Moffatt has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.