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• 50 min
  1. Where the thoughts dwell: history of neuroscience and introduction into neuroglia

  • Prof. Alexei Verkhratsky
• 35 min
  2. Astrocytes: definition, appearance and general physiology 1

  • Prof. Alexei Verkhratsky
• 30 min
  3. Astrocytes: definition, appearance and general physiology 2

  • Prof. Alexei Verkhratsky
• 39 min
  4. Glial calcium signalling

  • Prof. Alexei Verkhratsky
• 33 min
  5. Astroglial calcium signalling: what it could tell us

  • Prof. Dmitri Rusakov
• 42 min
  6. Neuronal-glial chemical transmission mediated by glutamate and ATP

  • Prof. Alexei Verkhratsky
• 27 min
  7. Energy and amino acid neurotransmitter metabolism in astrocytes

  • Prof. Helle Waagepetersen
• 49 min
  8. Mechanisms of glutamate release from astrocytes

  • Prof. Vladimir Parpura
• 37 min
  9. Cannabinoid type 1 receptors in astrocytes

  • Prof. Giovanni Marsicano
• 34 min
  10. Neuronal-glial anatomical plasticity in the hypothalamus

  • Dr. Stéphane H.R. Oliet
• 25 min
  11. General physiology of oligodendrocytes

  • Prof. Arthur M. Butt
• 35 min
  12. Neuropathology of microglia and oligodendrocytes

  • Prof. Arthur M. Butt
• 38 min
  13. Oligodendroglia/MCT1 are an unexpected contributor to CNS toxicity/neurodegeneration

  • Prof. Jeffrey D. Rothstein
• 41 min
  14. Physiology and pathophysiology of microglia

  • Prof. Dr. Uwe-Karsten Hanisch
• 39 min
  15. Properties of regulated exocytosis in astrocytes

  • Prof. Robert Zorec
• 49 min
  16. Exocytosis and gliocrine astroglia

  • Prof. Robert Zorec
• 37 min
  17. Noradrenergic hypothesis of neurodegeneration and astroglia

  • Prof. Robert Zorec
• 45 min
  18. Principles of astrogliopathology: from reactivity to atrophy and degeneration

  • Prof. Alexei Verkhratsky
• 23 min
  19. Regulation of synaptic plasticity by astroglia

  • Prof. Dmitri Rusakov
• 48 min
  20. Enteric glia: the glue of the enteric nervous system

  • Dr. Keith A. Sharkey
• 38 min
  21. Purinergic neuron-to-glia signaling in the enteric nervous system

  • Dr. Brian D. Gulbransen
• 43 min
  22. Astrocytes and Alexander disease: the first - but not last - primary astrocyte disease

  • Prof. Albee Messing
• 45 min
  23. Vesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons

  • Prof. Vladimir Parpura
• 43 min
  24. The impact of astrocyte mitochondrial ATP production on neuroprotection after stroke

  • Prof. James Lechleiter
• 33 min
  25. Hepatic encephalopathy in cirrhosis: a disorder of glial-neuronal signalling

  • Prof. Roger F. Butterworth
• 33 min
  26. Hepatic encephalopathy in acute liver failure: a primary neurogliopathy

  • Prof. Roger F. Butterworth
• 37 min
  27. Bi-directional communication at the neurovascular unit: implications for neuronal function

  • Prof. Jessica A. Filosa
• 51 min
  28. Astrocyte reactivity

  • Prof. Michael Sofroniew
• 36 min
  29. Roles of microglia in the healthy brain

  • Dr. Marie-Ève Tremblay
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  30. Astroglia in neuropathology

  • Prof. Alexei Verkhratsky
• 44 min
  31. Cell biology and physiology of astroglia

  • Prof. Alexei Verkhratsky
• 29 min
  32. General physiology of oligodendrocytes and Schwann cells

  • Prof. Arthur M. Butt

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Astrocytes - the homeostatic cells of the brain
3. Astrocytes may be labelled with GFAP antibodies
4. Heterogeneity of astrocytes (morphological)
5. Heterogeneity of astrocytes (functional)
6. Functions of astroglia
7. Embryonic neuro- and glio- genesis
8. Radial glial act as pathfinders for neuroblasts
9. Adult neurogenesis
10. Astrocytes promote and regulate synaptogenesis
11. Astrocytes control functional status of synapses
12. Defining functional architecture of grey matter
13. Astrocytes divide the grey matter into domains
14. Discovery of the BBB by Paul Ehrlich
15. Evolution of the BBB
16. Blood-Brain barrier - glial-vascular interface
17. Astroglial perivascular processes
18. Molecular traffic mechanisms through the BBB
19. Atrocytes regulate BBB development & function
20. The brain is one of the most vascularised organs
21. Astrocytes create neurovascular units
22. Brain energetics (1)
23. Brain energetics (2)
24. Lactate shuttle
25. Potassium buffering
26. Potassium siphoning in the single Muller glial cell
27. Control over water movements/redistribution
28. Astrocytes control brain glutamate homeostasis
29. Astrocytes are essential for Na+ homeostasis
30. Astrocytes provide CO2/H+ chemosensitivity
31. Signalling in neuronal-glial networks
32. The tripartite synapse
33. Tripartite synapse versus astroglial cradle
34. Propagating signalling waves in glial syncytium
35. Astrocytes as secretory cells
36. Signalling through the release of gliotransmitters
37. Conclusions

Topics Covered

• Astrocytes
• Functions of astroglia
• Adult neurogenesis
• The functional architecture of grey matter
• The blood-brain barrier and astrocytes
• Astroglial perivascular processes
• Mechanisms of molecular traffic through the blood-brain barrier
• Controlling microcirculation
• Metabolic support of neuronal networks
• Brain energetics
• The lactate shuffle
• Homeostatic function
• Water movements
• Signalling function
• Astroglia in synaptic transmission
• Astrocytes as secretory cells
• Distal signalling through the release of gliotransmitters

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on June 29, 2011
• Archived on April 28, 2022

Financial Disclosures

• Prof. Alexei Verkhratsky has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.