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1. Introduction
2. Alzheimer's disease (AD) overview
3. Alzheimer's disease prevalence
4. Prevalence of total and severe dementia
5. Neurodegenerative protein folding disorders
6. Dr. Alzheimer & the famous case of Auguste D.
7. Emil Kraepelin
8. Greenfield's Neuropathology
9. Major milestones in AD research
10. Gross pathology in Alzheimer's disease
11. MRI imaging in Alzheimer's disease
12. Hippocampus is involved in severe cases of AD
13. Neuropathological features of AD
14. APP
15. Abeta40 and Abeta42
16. Abeta species in variant Alzheimer's disease
17. Different plaque types in Alzheimer's disease
18. Amyloid in plaques and blood vessel walls
19. Ultrastructural features of senile/neuritic plaques
20. The role of Tau protein
21. Ultrastructural features of neurofibrillary tangles
22. Neurofibrillary tangles in Alzheimer's disease
23. Neurofibrillary tangle pathology in AD
24. Neurofibrillary pathology in AD
25. Stages of Alzheimer's disease
26. CERAD diagnosis of Alzheimer's disease (1)
27. CERAD diagnosis of Alzheimer's disease (2)
28. Post-mortem diagnosis of Alzheimer's disease
29. Alzheimer's disease inheritance
30. Mutations affecting the APP gene
31. The Abeta40/Abeta42 ratio (1)
32. APP mutations with cerebrovascular phenotype
33. The Abeta40/Abeta42 ratio (2)
34. Neuropathology of familial Alzheimer's disease
35. Spastic paraparesis and cotton wool plaques
36. Amyloid cascade hypothesis
37. Complement activation in Alzheimer's disease
38. Not only Abeta forms amyloid plaques in the CNS
39. ABri amyloid plaques in familial British dementia
40. Familial prion disease C-terminal truncation
41. Conclusions

Topics Covered

• Alzheimer's disease as the commonest neurodegenerative disease
• Alzheimer's disease as one of the protein folding disorders
• Alzheimer's disease is rarely inherited due to mutations of one of three genes
• Apolipoprotein E epsilon 4 allele as genetic risk factor for Alzheimer's disease
• Neuritic plaques
• Neurofibrillary tangles
• Amyloid-beta peptide
• Tau protein

Links

Series:

• Alzheimer's Disease

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on May 26, 2011

Financial Disclosures

• Prof. Tamas Revesz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.