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Printable Handouts
Navigable Slide Index
- Introduction
- Pregnancy and the immune system
- SLE and flares during pregnancy
- Pregnancies and patients studied
- Flare definition applied in pregnancy
- Physician judgement and disease activity index
- Flare definition
- Timing of SLE flares in pregnancy
- Flare frequency by timing of pregnancy
- ECLAM score / estrogen levels during pregnancy
- Can we know flare occurrences in advance ?
- Significant predictors of flares
- Pregnant women with SLE can have flares
- Gestational outcome in SLE
- Impact of lupus activity on obstetric outcome
- Gestational outcome in SLE: example
- Gestational outcome in renal SLE
- Identifying patients with a high risk of baby loss
- Predictors of adverse pregnancy outcome
- Predictors of obstetrical /neonatal complications
- Factors that predict prematurity and preeclampsia
- Autoantibodies that affect pregnancy outcome
- Antiphospholipid (APL) antibody definition
- Antiphospholipid (APL) antibody associations
- Beta-2 glycoprotein I (beta-2GPI)
- Two-hit theory in APS
- Placenta: the target of aPL
- Beta-2GPI binds the trophoblast cell membranes
- Revised classification for APS syndrome
- Antiphospholipid antibodies and autoimmunity
- APS is treatable cause of prgnancy loss
- Obstetrical complications
- Newborns from mothers with primary APS (1)
- Newborns from mothers with primary APS (2)
- Thrombosis in the offspring of APS patients
- Transplacental passage of IgG aPL (1)
- Transplacental passage of IgG aPL (2)
- aPL in 12 month old babies
- The influence on fetal development
- Mental developement and maternal autoAbs (1)
- Mental developement and maternal autoAbs (2)
- Clinical success and open questions
- Register of infants from mothers with APS
- IgG isotope can influence pregnancy
- Ro complex
- Anti-Ro/anti-La and autoimmunity
- Anti Ro/SS-A and gestational outcome
- Neonatal lupus model
- Anti Ro/SS-A and congenital heart block (CHB)
- Proposed mechanism of cardiac damage
- The diagnosis of CHB
- In utero detection of first-degree heart block
- Management of CHB
- Antenatal and postnatal exposure to DEX
- 11 CHB children with/without exposure to DEX
- T-cell evaluation in eight DEX exposed children
- Heteroduplex analysis on TCRBV chains
- Oligoclonal expansions of TCR repertoire
- Alessa - case study
- Second pregnancy - case study
- Acknowledgements and contacts
Topics Covered
- Pregnancy and the immune system
- SLE flares during pregnancy
- Gestational outcome in SLE
- Predictors of obstetrical and neonatal complications in SLE
- Autoantibodies that can affect pregnancy outcome: antiphospholipid antibodies
- Obstetrical complications and newborns outcome in antiphospholipid syndrome
- Autoantibodies that can affect pregnancy outcome: anti-Ro/SS-A antibodies
- Neonatal lupus
- Congenital heart block and in utero exposure to dexamethasone
Links
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Talk Citation
Tincani, A. (2007, October 1). Pregnancy in autoimmune rheumatic diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/OLRV6867.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Angela Tincani has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.