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1. Introduction
2. Overview
3. Epilepsy - definition
4. Epilepsy - common mechanisms
5. Epileptogenesis
6. Etiology of epilepsy
7. Epileptogenic process
8. Epileptogenesis schematic
9. Acute symptomatic seizures
10. Electrographic seizure - EEG recording
11. Recurrence of seizures over time
12. Pathophysiology of acute symptomatic seizures
13. Latent period
14. Late seizures and epilepsy
15. Animal models of epileptogenesis (1)
16. Animal models of epileptogenesis (2)
17. Pilocarpine model
18. Mossy fiber sprouting after pilocarpine SE
19. Kainate model
20. Seizures after kainate SE
21. Kindling model
22. Fluid percussion injury model
23. Progressive MRI changes in epileptogenesis
24. Late posttraumatic seizures
25. Risk of epilepsy after brain insults
26. Risk of epilepsy after brain injury (1)
27. Risk of epilepsy after brain injury (2)
28. Risk of epilepsy after TBI
29. Post-traumatic seizures
30. Recurrence risk after seizures in TBI
31. Incidence of seizures after stroke
32. Stroke
33. Methodological flaws
34. Seizure-free patients after stroke
35. Stroke severity and seizures
36. Seizures by stroke subtype
37. Seizures by infarct subtype
38. Risk of late seizures
39. Seizure incidence and neurosurgical procedures
40. Seizure incidence and brain tumor
41. Seizure incidence and CNS infection
42. Seizure incidence and febrile seizures
43. Status epilepticus - definitions
44. Status epilepticus & epilepsy
45. Status epilepticus - precipitants
46. Clinical trials for prevention of epilepsy
47. Epilepsy prophylaxis vs. treatment trials
48. AEG study design
49. Trial populations
50. Subject selection
51. Trial populations - other factors
52. Drug options to use in a prophylaxis trial
53. Treatment time window
54. Trial endpoints (1)
55. Trial endpoints (2)
56. Previous antiepileptogenesis trials
57. Epilepsy prophylaxis trials - traumatic brain injury
58. Epilepsy prophylaxis trials - other risk factors
59. Existing AEG trials
60. AEG studies limitations
61. Prevention of late seizure after TBI
62. Seizure prevention trials after TBI
63. Future directions
64. Monitoring epileptogenesis
65. Monitoring epileptogenesis-potential techniques
66. Biomarkers for epileptogenesis
67. Inclusion and validation of biomarkers
68. Interictal Epileptiform Discharges (IED)
69. IEDs - limitations
70. Transcranial Magnetic Stimulation
71. Neuroimaging may help predict epilepsy
72. MRI may help predict epilepsy
73. Future studies to prevent epilepsy

Topics Covered

• Introduction
• Causes of epilepsy
• Epileptogenesis
• Initial insult / Acute symptomatic seizures
• Latent period
• Late seizures
• Epilepsy
• Animal models of epileptogenesis
• Risk of epilepsy after brain insults
• Clinical trial design
• Review of prophylaxis trials
• Future directions

Links

Series:

• Epilepsy and Seizures

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on May 3, 2011

Financial Disclosures

• Dr. Susan T. Herman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.