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Biomedical Basics

Gene regulation and expression

  • Created by Henry Stewart Talks
Published on March 31, 2026   4 min

A selection of talks on Genetics & Epigenetics

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This talk introduces gene regulation and expression, using it as a basis for further exploration of the fundamental mechanisms of gene regulation, including how promoter regions, transcription factors, and regulatory elements control gene expression. We will explore the roles of enhancers, silencers, epigenetic modifications, and chromatin remodeling in fine tuning genetic output. The lecture will discuss post transcriptional regulation such as RNA processing, alternative splicing, and RNA stability, as well as translational control mechanisms. Altogether, these interconnected layers enable cells to precisely regulate gene activity, adapt to environmental cues, and support complex functions in multicellular organisms. Gene regulation ensures each cell type expresses only the genes it needs at the right time and amount. This selectivity starts with DNA promoter regions, where the transcription machinery assembles. General transcription factors and RNA polymerase two, bind to the promoter, initiating gene transcription. Promoter elements like tata boxes or CPG islands help control gene responsiveness. Regulation also involves enhancers, silencers and motifs bound by regulatory proteins, enabling precise control of a gene activity. The specificity of gene expression relies on a diverse array of transcription factors. These proteins recognize unique DNA motifs in regulatory regions and act as gene switches. Activators bind to distant enhancers,

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