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- Advances in the Understanding of Etiology (I)
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30 min
1. Infection and autoimmunity: a two-way relationship- Dr. Ricard Cervera
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35 min
2. Autoimmunity and atherosclerosis- Prof. Johan Frostegard
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47 min
3. Endothelium and autoimmunity- Prof. Pier Luigi Meroni
- Advances in the Understanding of Etiology (II)
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22 min
4. Prolactin has a pathogenic role in systemic lupus erythematosus- Prof. Luis Jara-Quezada
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44 min
5. Sjögren's syndrome: current knowledge and future prospects- Prof. Athanasios G. Tzioufas
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51 min
6. Genetic and environmental triggers of autoimmune thyroid diseases- Prof. Yaron Tomer
- Advances in Pathogenesis and Clinical Manifestation
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38 min
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20 min
8. Pathogenic mechanisms of autoantibodies: circulating and local antibodies that form immune complexes- Dr. Luís Eduardo Coelho Andrade
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34 min
9. Pathogenic mechanisms of autoantibodies: antibodies to intracellular and membrane-bound antigens- Dr. Luís Eduardo Coelho Andrade
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43 min
10. What causes primary biliary cholangitis?- Dr. M. Eric Gershwin
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30 min
11. Capillaroscopy in autoimmune rheumatic diseases- Prof. Maurizio Cutolo
- Advances in Diagnostic Methodologies (I)
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26 min
12. The past, present & future of ANA testing: history and challenges of ANA- Prof. Marvin J. Fritzler
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33 min
13. The past, present & future of ANA testing: changing bandwidth and future of ANA- Prof. Marvin J. Fritzler
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36 min
14. Diagnostic methods in autoimmunity- Mr. Steven Binder
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24 min
15. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 1- Prof. Chaim Putterman
- Dr. Noa Schwartz
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28 min
16. Systemic lupus erythematosus: novel aspects of pathogenesis and treatment 2- Prof. Chaim Putterman
- Dr. Noa Schwartz
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48 min
17. Novel aspects of systemic sclerosis- Prof. Gabriele Valentini
- Advances in Diagnostic Methodologies (II)
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46 min
18. An update on the multiple faces of celiac disease- Prof. Aaron Lerner
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23 min
19. Protective autoantibodies- Prof. Elias Toubi
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32 min
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44 min
21. Rheumatic fever: a model of a post-infectious autoimmune disease- Prof. Jorge Kalil
- Treatments of autoimmune diseases
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38 min
22. Intravenous immunoglobulins: clinical evidence- Prof. Shaye Kivity
- Latest Developments in the Field
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26 min
23. Adjuvants and autoimmunity- Dr. Eitan Israeli
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46 min
24. Antiphospholipid syndrome (APS): from pathogenesis to treatment- Prof. Roger Levy
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24 min
25. Vitamin D and autoimmunity- Dr. Shir Azrielant
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28 min
26. Pregnancy in rheumatic diseases- Prof. Pier Luigi Meroni
- Archived Lectures *These may not cover the latest advances in the field
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47 min
27. Pathogenic mechanisms of autoantibodies- Prof. Cees Kallenberg
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41 min
28. B lymphocytes on the frontline of autoimmunity- Prof. Pierre Youinou
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42 min
29. Apoptotic cell clearance deficiency- Prof. Martin Herrmann
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34 min
30. Auto-antibodies as predictors of autoimmune disease- Dr. Nicola Bizzaro
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46 min
31. Innate immunity and natural autoantibodies- Prof. Luc Mouthon
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45 min
32. Accelerated atherosclerosis in autoimmune rheumatic disease- Dr. Andrea Doria
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47 min
33. Pregnancy in autoimmune rheumatic diseases- Prof. Angela Tincani
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42 min
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39 min
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24 min
36. Immunologic mechanisms in systemic lupus erythematosus- Prof. Kok-Yong Fong
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23 min
37. Osteoimmunology- Prof. João Eurico Fonseca
- Ms. Joana Caetano-Lopes
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43 min
38. ANCA-associated systemic vasculitides- Prof. Loic Guillevin
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23 min
39. The common origin for diverse autoimmune diseases- Prof. Juan-Manuel Anaya
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76 min
40. Anti-cytokine therapy in rheumatoid arthritis- Prof. Piercarlo Sarzi-Puttini
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40 min
41. Sjogren's syndrome: autoimmune epithelitis- Prof. Haralampos Moutsopoulos
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31 min
42. Vitamin D and autoimmunity- Dr. Howard Amital
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25 min
43. Intravenous immunoglobulins: myth and reality- Prof. Zera Tellier
Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Apoptotic cell clearance deficiency
- Apoptotic and necrotic cell death
- Apoptotic cell death during development
- The balance of life and death
- Inducers of apoptosis
- Apoptosis vs. primary necrosis
- The sites of apoptosis
- Exposure during apoptosis of phosphatidylserine
- Exposure of phosphatidylserine on viable cells
- Oxidation of phosphatidylserine
- Cyt c as a catalyst for selective oxidation of PS
- Inflammatory molecules in activated cells
- Inflammatory molecules in early apoptotic cells
- Inflammatory molecules in late apoptotic cells
- Inflammatory molecules in necrotic cells
- Summary on inflammatory molecules in apoptosis
- Clearance of dying cells
- Communication network of apoptosis
- Apoptotic cell - immune reaction/tolerance
- Necrotic cell - immune reaction/tolerance
- PS molecules sequestered inside cells
- Phosphatidylserine recognized by several ligands
- Cells bleb in later phases of apoptosis
- Late apoptotic cells recognized by several ligands
- Abnormalities in adaptor molecules linked to SLE
- PS-receptor is nuclear protein
- Summary - the clearance of apoptotic cells
- Repulsion activity with CD31
- Putative model of phagocyte attraction
- iPLA-2 induces the release of LPC
- Model of caspase and iPLA-2
- Oxydative stress cause oxydation of phospholipids
- Anti-inflammatory effects of apoptotic cells
- Anti-inflammatory effect on monocytes with LPS
- AxV skews cytokine secretion
- Blocking clearance restores Ig response
- Balance of inflamation - bacteria and viruses
- Balance of inflamation - early apoptotic cells
- Balance of inflamation - late apoptotic cells
- Systemic lupus erythematosus
- Example of patient with SLE
- Twin studies of SLE
- SLE clinical characteristics
- SLE etiology
- SLE pathology
- Apoptotic cells accumulation in cultured PBMC
- Clearance of apoptotic cells is impaired in MoMa
- Diseases with accumulation of apoptotic cells
- Apoptotic cell accumulation in germinal centers
- Uningested apoptotic nuclei in germinal center
- Germinal center sections with SLE
- Impaired clearance of apoptotic nuclei in SLE (1)
- Impaired clearance of apoptotic nuclei in SLE (2)
- Immune fluorescence images by CFM
- Germinal center of normal healthy donor
- Germinal center during somatic mutations
- Apoptotic remnants accumulate in macrophages
- Clearance failure in SLE patients
- Summmary - AC accumulation in germinal centers
- Apoptotic trash as an antigen
- Phagocytic defect and anti-dsDNA autoAb
- Binding specificity of 33.C9 variants
- 33.C9 Ab and anti-dsDNA activity
- IgG autoAb gained DNA reactivity
- Apoptotic cells in skin of patients with CLE
- Apoptotic cells in skin with CLE after UV exposure
- Graph of accumulation of apoptotic cells
- Humoral factors help clear apoptotic cells
- Summary of humoral factors
- Low clearance in stem cell-derived phagocytes
- Stem cells show proliferation in vitro V15.3.05 (1)
- Stem cells show proliferation in vitro V15.3.05 (2)
- Reduced uptake of IgG-coated beads V9.03
- Summary of stem cells-derived phagocytes
- Animal models for clearance deficiency
- Gene targeted mice with SLE-like symptoms
- Low apoptotic cell clearance is an SLE risk factor
- Supporting institutions
- Acknowledgements
Topics Covered
- Anti-inflammatory and immunosuppressive effects of apoptotic cells
- Autoimmune disease and clearance of dying cells
- Clearance deficiency of apoptotic cells
- Germinal centre tingible body macrophage deficiency
- Model for the generation of nuclear autoimmunity
- Annexin V as adjuvans for irradiated tumor cells
Links
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Talk Citation
Herrmann, M. (2007, October 1). Apoptotic cell clearance deficiency [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/192/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Martin Herrmann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
