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1. Introduction
2. Outline
3. Apoptotic cell clearance deficiency
4. Apoptotic and necrotic cell death
5. Apoptotic cell death during development
6. The balance of life and death
7. Inducers of apoptosis
8. Apoptosis vs. primary necrosis
9. The sites of apoptosis
10. Exposure during apoptosis of phosphatidylserine
11. Exposure of phosphatidylserine on viable cells
12. Oxidation of phosphatidylserine
13. Cyt c as a catalyst for selective oxidation of PS
14. Inflammatory molecules in activated cells
15. Inflammatory molecules in early apoptotic cells
16. Inflammatory molecules in late apoptotic cells
17. Inflammatory molecules in necrotic cells
18. Summary on inflammatory molecules in apoptosis
19. Clearance of dying cells
20. Communication network of apoptosis
21. Apoptotic cell - immune reaction/tolerance
22. Necrotic cell - immune reaction/tolerance
23. PS molecules sequestered inside cells
24. Phosphatidylserine recognized by several ligands
25. Cells bleb in later phases of apoptosis
26. Late apoptotic cells recognized by several ligands
27. Abnormalities in adaptor molecules linked to SLE
28. PS-receptor is nuclear protein
29. Summary - the clearance of apoptotic cells
30. Repulsion activity with CD31
31. Putative model of phagocyte attraction
32. iPLA-2 induces the release of LPC
33. Model of caspase and iPLA-2
34. Oxydative stress cause oxydation of phospholipids
35. Anti-inflammatory effects of apoptotic cells
36. Anti-inflammatory effect on monocytes with LPS
37. AxV skews cytokine secretion
38. Blocking clearance restores Ig response
39. Balance of inflamation - bacteria and viruses
40. Balance of inflamation - early apoptotic cells
41. Balance of inflamation - late apoptotic cells
42. Systemic lupus erythematosus
43. Example of patient with SLE
44. Twin studies of SLE
45. SLE clinical characteristics
46. SLE etiology
47. SLE pathology
48. Apoptotic cells accumulation in cultured PBMC
49. Clearance of apoptotic cells is impaired in MoMa
50. Diseases with accumulation of apoptotic cells
51. Apoptotic cell accumulation in germinal centers
52. Uningested apoptotic nuclei in germinal center
53. Germinal center sections with SLE
54. Impaired clearance of apoptotic nuclei in SLE (1)
55. Impaired clearance of apoptotic nuclei in SLE (2)
56. Immune fluorescence images by CFM
57. Germinal center of normal healthy donor
58. Germinal center during somatic mutations
59. Apoptotic remnants accumulate in macrophages
60. Clearance failure in SLE patients
61. Summmary - AC accumulation in germinal centers
62. Apoptotic trash as an antigen
63. Phagocytic defect and anti-dsDNA autoAb
64. Binding specificity of 33.C9 variants
65. 33.C9 Ab and anti-dsDNA activity
66. IgG autoAb gained DNA reactivity
67. Apoptotic cells in skin of patients with CLE
68. Apoptotic cells in skin with CLE after UV exposure
69. Graph of accumulation of apoptotic cells
70. Humoral factors help clear apoptotic cells
71. Summary of humoral factors
72. Low clearance in stem cell-derived phagocytes
73. Stem cells show proliferation in vitro V15.3.05 (1)
74. Stem cells show proliferation in vitro V15.3.05 (2)
75. Reduced uptake of IgG-coated beads V9.03
76. Summary of stem cells-derived phagocytes
77. Animal models for clearance deficiency
78. Gene targeted mice with SLE-like symptoms
79. Low apoptotic cell clearance is an SLE risk factor
80. Supporting institutions
81. Acknowledgements

Topics Covered

• Anti-inflammatory and immunosuppressive effects of apoptotic cells
• Autoimmune disease and clearance of dying cells
• Clearance deficiency of apoptotic cells
• Germinal centre tingible body macrophage deficiency
• Model for the generation of nuclear autoimmunity
• Annexin V as adjuvans for irradiated tumor cells

Links

Series:

• Autoimmunity

Categories:

• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. Martin Herrmann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.