Hello. My name is Dr. Braden Kuo.
I'm a gastroenterologist and physician at
the Gastrointestinal Unit at Massachusetts General Hospital and Harvard Medical School.
Today, I'll be talking about disorders of gastric function,
specifically gastroparesis and functional dyspepsia.
Today, as part of the agenda,
we'll be talking about the symptoms, definitions,
and epidemiology, reviewing a little bit about
the pathophysiology and also the treatment paradigms.
Gastroparesis as a definition is delayed gastric emptying in
the absence of a fixed mechanical obstruction of the pylorus or small intestine.
In the bigger complex,
one can think about diabetic gastropathy,
which is a symptom complex of functional, contractile, electrical,
and sensory dysfunction of the stomach associated with diabetes.
Patients can have pain or discomfort,
rapid or even delayed emptying.
Some suggestive symptoms include early satiety, anorexia, food avoidance,
bloating and fullness, heartburn, nausea,
abdominal pain or discomfort,
weight loss, postprandial vomiting.
Fifty percent of patients in
general practice clinics or in gastroenterology clinics may have
motility disorders and 76 percent of patients in
a diabetic clinic had chronic or recurrent symptoms consistent with gastroparesis,
which ultimately may complicate the glucose regulation.
Fifty percent of patients with non-ulcer dyspepsia or
functional dyspepsia have delayed gastric emptying with impaired antral motility.
From the gastroparesis consortium,
the burden of illness,
impaired quality life, and co-morbidities
associated with gastroparesis are highly significant.
Majority, over two-thirds of the patients do not improve over time and obesity is common
amongst patients with gastroparesis and it's associated
with differences in clinical phenotype with a worse outcome.
Post-infectious gastroparesis is suspected in a significant proportion of patients.