Disorders of gastric function: gastroparesis and functional dyspepsia 1

Published on January 11, 2011 Updated on April 29, 2020   39 min

Other Talks in the Series: Gastroenterology and Hepatology

0:00
Hello. My name is Dr. Braden Kuo. I'm a gastroenterologist and physician at the Gastrointestinal Unit at Massachusetts General Hospital and Harvard Medical School. Today, I'll be talking about disorders of gastric function, specifically gastroparesis and functional dyspepsia.
0:18
Today, as part of the agenda, we'll be talking about the symptoms, definitions, and epidemiology, reviewing a little bit about the pathophysiology and also the treatment paradigms.
0:30
Gastroparesis as a definition is delayed gastric emptying in the absence of a fixed mechanical obstruction of the pylorus or small intestine.
0:39
In the bigger complex, one can think about diabetic gastropathy, which is a symptom complex of functional, contractile, electrical, and sensory dysfunction of the stomach associated with diabetes. Patients can have pain or discomfort, rapid or even delayed emptying.
0:56
Some suggestive symptoms include early satiety, anorexia, food avoidance, bloating and fullness, heartburn, nausea, abdominal pain or discomfort, weight loss, postprandial vomiting.
1:11
Fifty percent of patients in general practice clinics or in gastroenterology clinics may have motility disorders and 76 percent of patients in a diabetic clinic had chronic or recurrent symptoms consistent with gastroparesis, which ultimately may complicate the glucose regulation. Fifty percent of patients with non-ulcer dyspepsia or functional dyspepsia have delayed gastric emptying with impaired antral motility.
1:35
From the gastroparesis consortium, the burden of illness, impaired quality life, and co-morbidities associated with gastroparesis are highly significant. Majority, over two-thirds of the patients do not improve over time and obesity is common amongst patients with gastroparesis and it's associated with differences in clinical phenotype with a worse outcome. Post-infectious gastroparesis is suspected in a significant proportion of patients.
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Disorders of gastric function: gastroparesis and functional dyspepsia 1

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