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Hello. My name is Dr. Braden Kuo.
I'm a gastroenterologist and physician at
the Gastrointestinal Unit at Massachusetts General Hospital and Harvard Medical School.
Today, I'll be talking about disorders of gastric function,
specifically gastroparesis and functional dyspepsia.
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Today, as part of the agenda,
we'll be talking about the symptoms, definitions,
and epidemiology, reviewing a little bit about
the pathophysiology and also the treatment paradigms.
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Gastroparesis as a definition is delayed gastric emptying in
the absence of a fixed mechanical obstruction of the pylorus or small intestine.
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In the bigger complex,
one can think about diabetic gastropathy,
which is a symptom complex of functional, contractile, electrical,
and sensory dysfunction of the stomach associated with diabetes.
Patients can have pain or discomfort,
rapid or even delayed emptying.
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Some suggestive symptoms include early satiety, anorexia, food avoidance,
bloating and fullness, heartburn, nausea,
abdominal pain or discomfort,
weight loss, postprandial vomiting.
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Fifty percent of patients in
general practice clinics or in gastroenterology clinics may have
motility disorders and 76 percent of patients in
a diabetic clinic had chronic or recurrent symptoms consistent with gastroparesis,
which ultimately may complicate the glucose regulation.
Fifty percent of patients with non-ulcer dyspepsia or
functional dyspepsia have delayed gastric emptying with impaired antral motility.
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From the gastroparesis consortium,
the burden of illness,
impaired quality life, and co-morbidities
associated with gastroparesis are highly significant.
Majority, over two-thirds of the patients do not improve over time and obesity is common
amongst patients with gastroparesis and it's associated
with differences in clinical phenotype with a worse outcome.
Post-infectious gastroparesis is suspected in a significant proportion of patients.
