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Biomedical Basics

Tyrosine kinase receptors and growth factors

  • Created by Henry Stewart Talks
Published on February 26, 2026   4 min

A selection of talks on Cell Biology

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The following session we'll cover tyracine kinase receptors and growth factors, focusing on the structure and function of tyracine kinase receptors, RTKs, how they transmit external signals through ligand induced dimerization and activation, and the major intracellular pathways they initiate, such as MAPK and PI three K. We will examine the roles of key growth factors like EGF and insulin and explore how RTK signaling governs crucial cellular decisions in development and adult physiology. Finally, we will discuss the consequences of RTK dysregulation in diseases like cancer and consider the therapeutic potential of targeting RTKs. Tyracine kinase receptors, often called RTKs, are key regulators of cellular communication. These transmembrane proteins consist of an extracellular ligand binding domain, a single transmembrane alpha helix, and an intracellular tyrosine kinase domain, which transfers phosphate groups from ATP to specific tyrosine residues. RTKs interpret external signals like growth factors and convert them into cellular responses. Malfunctioning RTKs can contribute to diseases such as cancer, making them important therapeutic targets. Activation of tyracine kinase receptors begins with ligand binding, often a growth factor to the extracellular domain. This induces receptor dimerisation, bringing two kinase domains together for autophosphorylation,

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