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- Cellular Mechanisms of Mitochondrial Biogenesis in Health
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23 min
1. Nuclear control of electron transport chain gene expression- Dr. Glenn C. Rowe
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48 min
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17 min
3. Protein import into mitochondria- Dr. Trevor Lithgow
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39 min
4. Mitochondrial phospholipid synthesis and incorporation- Prof. Grant Hatch
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23 min
5. Mitochondrial DNA replication and transcription- Prof. Julio Montoya
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37 min
6. Mitochondrial production of reactive oxygen species 1- Prof. Martin Brand
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22 min
7. Mitochondrial production of reactive oxygen species 2- Prof. Martin Brand
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35 min
8. Mitophagy - the degradation of dysfunctional organelles- Dr. Anna Vainshtein
- Mitochondrial Biogenesis in Physiological Conditions
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21 min
9. Thyroid hormone and mitochondrial biogenesis- Dr. Joachim Weitzel
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28 min
10. Exercise-induced mitochondrial biogenesis in muscle 1- Prof. David Hood
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37 min
11. Exercise-induced mitochondrial biogenesis in muscle 2- Prof. David Hood
- Mitochondrial Biogenesis in Aging and Disease
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33 min
12. Mitochondrial diseases: an update- Dr. Ayesha Saleem
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59 min
13. Exercise and nutrition in mitochondrial disorders- Prof. Mark Tarnopolsky
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42 min
14. Mitochondrial disorders and neurodegeneration- Dr. Jan-Willem Taanman
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33 min
15. Reprogramming oxidative phosphorylation in cancer- Prof. José Cuezva
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44 min
16. Possible roles of mitochondrial biogenesis in aging- Dr. Aubrey de Grey
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31 min
17. Mitochondria in reproduction and fertility: mitochondria and gametes 1- Prof. Pascale May Panloup
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30 min
18. Mitochondria in reproduction and fertility: mitochondria and embryo 2- Prof. Pascale May Panloup
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35 min
19. Mitochondrial morphology and ultrastructure in skeletal muscle- Prof. Martin Picard
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19 min
20. Improving mitochondrial phenotypes with pharmaceuticals- Prof. Christopher Perry
- Mitochondria, Cell Signaling and Apoptosis
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42 min
21. Mitochondrial permeability transition- Prof. John Lemasters
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47 min
22. Pathways of apoptosis in muscle 1- Prof. Stephen E. Alway
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42 min
23. Pathways of apoptosis in muscle 2- Prof. Stephen E. Alway
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21 min
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32 min
- Archived Lectures *These may not cover the latest advances in the field
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44 min
26. Reactive oxygen species and myocardial apoptosis- Dr. Zhi-Qing Zhao
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34 min
27. Mitochondrial biogenesis as a result of exercise- Dr. Darrell Neufer
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30 min
28. Mechanisms of mitochondrial fusion and fission- Dr. Luca Scorrano
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30 min
29. Mitochondrial heterogeneity in cells- Dr. Tony Collins
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40 min
30. Mitochondrial diseases: an update- Prof. Salvatore DiMauro
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41 min
31. Calcium signaling and mitochondrial function- Prof. David Nicholls
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35 min
32. Mitochondrial biogenesis during gametogenesis and embryonic development- Prof. Pascal Reynier
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33 min
33. Mitochondrial complex assembly- Dr. Leo Nijtmans
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33 min
34. Evolutionary and developmental variation in muscle mitochondrial content- Prof. Christopher Moyes
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33 min
35. Muscle mitochondrial function and biogenesis with aging- Dr. Russell Hepple
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23 min
36. The mitochondrial pathway in apoptosis- Prof. Douglas Green
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40 min
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38 min
38. Mitochondrial disorders and neurodegeneration- Prof. Anthony Schapira
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43 min
39. Respiration, reactive oxygen species and uncoupling proteins- Prof. Martin Brand
Printable Handouts
Navigable Slide Index
- Introduction
- Apoptosis and programmed cell death
- An example of cell death which is also apoptosis
- Morphological changes during apoptosis
- Apoptosis involves characteristic cellular changes
- Occurrence of apoptosis
- Induction of apoptosis
- Caspases (1)
- Caspase activation
- Caspases (2)
- Initiator caspase activation
- Caspases (3)
- Death folds
- Inhibitor of apoptosis proteins
- Apoptotic pathways in mammals
- Mitochondrial pathway of apoptosis (1)
- Release of cytochrome c
- Apoptosome
- Genetic evidence from knock-out mice
- Mitochondrial outer membrane permeabilization
- The Bcl-2 family proteins
- Bcl-2 family proteins have similar structures
- The pro-apoptotic proteins Bax and Bak
- Activation and repression
- Bcl-2 protein bound to BH3 peptide
- Activation and de-repression
- Bcl-2 "addiction"
- Bid is activated by proteolytic cleavage
- MOMP also promotes apoptosis inhibiting XIAP
- Two types of MOMP
- The mitochondrial permeability transition
- Loss of mitochondrial membrane potential
- Mice lacking cyclophilin D
- Types of MOMP
- Mitochondria undergo fission and fusion (1)
- Mitochondria undergo fission and fusion (2)
- Mitochondria fragment upon MOMP (1)
- Mitochondria fragment upon MOMP (2)
- Mitochondrial fission and MOMP
- Caspase-independent cell death (CICD)
- Cells die in the absence of caspase activation
- CICD in the developing interdigital web
- Mitochondrial pathway of apoptosis (2)
Topics Covered
- Apoptosis and programmed cell death
- Apoptosis occurrence and induction
- Role of caspase proteases in apoptosis
- Apoptotic pathways in mammals
- Mitochondrial pathway of apoptosis
- The Bcl-2 family proteins
- Mitochondrial permeability transition
- Bax/Bak "pore"
- Mitochondrial fission and outer membrane permeabilization
- Caspase-independent cell death
Talk Citation
Green, D. (2007, October 1). The mitochondrial pathway in apoptosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 11, 2025, from https://doi.org/10.69645/UJQQ2497.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Douglas Green has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
