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1. Introduction
2. Neurochemical research in autism
3. Acetylcholine GABA and glutamate research
4. Endogenous opioids, oxytocin and AVP research
5. The dopamine research
6. The stress response system in autism
7. Neurochemical basal functioning in autism
8. Neurochemical acute response in autism
9. Circadian urinary excretion of norepinephrine
10. Circadian urinary excretion of epinephrine
11. Serotonin system alterations in autism
12. Serotonin - some background
13. Location of serotonergic neurons in the CNS
14. Serotonin uptake in the platelet
15. Rationale for the study of 5-HT in autism
16. Intriguing recent 5-HT findings
17. Increased platelet serotonin in autism
18. Platelet serotonin in the PDD group
19. Increased platelet serotonin
20. Platelet serotonin in 5-20 year-old Dutch subjects
21. Infant and maternal platelet serotonin heritability
22. The platelet in autism
23. Peripheral serotonin levels prediction model
24. Urinary 5-HIAA excretion in autism (1)
25. Urinary 5-HIAA excretion in autism (2)
26. Platelet serotonin in autism - future directions
27. Neurochemical alterations in autism
28. Reduced 5-HT2A receptor expression
29. Overview of 5HT-2A findings in autism
30. 5-HT2 receptor binding in parents of autists
31. 5-HT2A receptor in autism: future directions
32. Melatonin in autism
33. Control and regulation of melatonin secretion
34. Reduced melatonin excretion in autism
35. Abnormal melatonin synthesis in autism
36. Circadian urinary excretion of melatonin in autism
37. Excretion of 6-SM in hyperserotonemic autism
38. Melatonin in autism: future directions
39. Summary
40. Thank you
41. Collaborators
42. References

Topics Covered

• Overview of neurochemical research in autism
• Acetylcholine
• Glutamate
• GABA
• Endogenous opioids
• Oyxtocin & AVP
• Dopamine
• Stress response systems
• Noradrenergic/sympathetic nervous system
• The adrenomedullary system and the HPA axis
• Serotonin and melatonin

Links

Series:

• Autism and Autism Spectrum Disorders

Categories:

• Neuroscience

Talk Citation

Publication History

• Published on September 29, 2010

Financial Disclosures

• Dr. George Anderson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.