Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Mitochondrial permeability transition (MPT)
3. Mitochondrial swelling after MPT induction
4. Calcium induced MPT
5. Calcium transition-inducing agents
6. Discrepancies of the consensus model
7. Alternative protein misfolding model of the MPT
8. Low vs. high mastoparane doses effect on MPT
9. Heat shock effect on Hsp25 protein expression
10. Shift of isoelectric point of RISP at MPT onset
11. Phosphatase shifts pI of RISP
12. RISP and complex III migration in native gels
13. The activity of CsA in immune response and MPT
14. Amphiphiles and the MPT
15. Mitochondrial swelling in Reye's syndrome
16. Salicylate but not Aspirin induces the MPT
17. Substances in Reye-related drug toxicities
18. Does the MPT really occur in living cells?
19. Ischemia\reperfusion and MPT in living cells
20. Inner membrane permeabilization after reperfusion
21. Cell killing in pH-dependent reperfusion injury
22. TNF-alpha-induced depolarization and permeability
23. CsA blocks TNF-alpha
24. Apoptotic signaling after TNF-alpha
25. Events after ischemia/reperfusion in rat liver
26. Oxidative stress-induced MPT
27. Necrapoptosis
28. Cell death signals converging at the mitochondria
29. Role of MPT in cells that are not dying
30. Mitochondrial depolarization inhibition by CsA
31. Mitochondrial autophagy (mitophagy)
32. Mitophagy in GFP-LC3 mouse hepatocytes
33. Degradation of mtDNA by mitophagy
34. Mitophagy: summary
35. MPT - summary
36. References (1)
37. References (2)
38. References (3)
39. References (4)
40. References (5)
41. References (6)

Topics Covered

• Factors regulating opening of permeability transition pores
• Models of permeability transition pore composition
• Discrepancies of consensus model
• Protein misfolding and the MPT
• Rieske iron sulfur protein
• Reye's syndrome
• Ischemia/reperfusion and oxidative stress
• Apoptosis
• Mitochondrial autophagy (mitophagy)
• Necrapoptosis

Links

Series:

• Mitochondrial Biogenesis

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. John Lemasters has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.