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- Cellular Mechanisms of Mitochondrial Biogenesis in Health
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23 min
1. Nuclear control of electron transport chain gene expression- Dr. Glenn C. Rowe
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48 min
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17 min
3. Protein import into mitochondria- Dr. Trevor Lithgow
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39 min
4. Mitochondrial phospholipid synthesis and incorporation- Prof. Grant Hatch
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23 min
5. Mitochondrial DNA replication and transcription- Prof. Julio Montoya
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37 min
6. Mitochondrial production of reactive oxygen species 1- Prof. Martin Brand
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22 min
7. Mitochondrial production of reactive oxygen species 2- Prof. Martin Brand
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35 min
8. Mitophagy - the degradation of dysfunctional organelles- Dr. Anna Vainshtein
- Mitochondrial Biogenesis in Physiological Conditions
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21 min
9. Thyroid hormone and mitochondrial biogenesis- Dr. Joachim Weitzel
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28 min
10. Exercise-induced mitochondrial biogenesis in muscle 1- Prof. David Hood
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37 min
11. Exercise-induced mitochondrial biogenesis in muscle 2- Prof. David Hood
- Mitochondrial Biogenesis in Aging and Disease
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33 min
12. Mitochondrial diseases: an update- Dr. Ayesha Saleem
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59 min
13. Exercise and nutrition in mitochondrial disorders- Prof. Mark Tarnopolsky
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42 min
14. Mitochondrial disorders and neurodegeneration- Dr. Jan-Willem Taanman
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33 min
15. Reprogramming oxidative phosphorylation in cancer- Prof. José Cuezva
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44 min
16. Possible roles of mitochondrial biogenesis in aging- Dr. Aubrey de Grey
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31 min
17. Mitochondria in reproduction and fertility: mitochondria and gametes 1- Prof. Pascale May Panloup
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30 min
18. Mitochondria in reproduction and fertility: mitochondria and embryo 2- Prof. Pascale May Panloup
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35 min
19. Mitochondrial morphology and ultrastructure in skeletal muscle- Prof. Martin Picard
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19 min
20. Improving mitochondrial phenotypes with pharmaceuticals- Prof. Christopher Perry
- Mitochondria, Cell Signaling and Apoptosis
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42 min
21. Mitochondrial permeability transition- Prof. John Lemasters
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47 min
22. Pathways of apoptosis in muscle 1- Prof. Stephen E. Alway
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42 min
23. Pathways of apoptosis in muscle 2- Prof. Stephen E. Alway
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21 min
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32 min
- Archived Lectures *These may not cover the latest advances in the field
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44 min
26. Reactive oxygen species and myocardial apoptosis- Dr. Zhi-Qing Zhao
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34 min
27. Mitochondrial biogenesis as a result of exercise- Dr. Darrell Neufer
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30 min
28. Mechanisms of mitochondrial fusion and fission- Dr. Luca Scorrano
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30 min
29. Mitochondrial heterogeneity in cells- Dr. Tony Collins
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40 min
30. Mitochondrial diseases: an update- Prof. Salvatore DiMauro
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41 min
31. Calcium signaling and mitochondrial function- Prof. David Nicholls
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35 min
32. Mitochondrial biogenesis during gametogenesis and embryonic development- Prof. Pascal Reynier
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33 min
33. Mitochondrial complex assembly- Dr. Leo Nijtmans
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33 min
34. Evolutionary and developmental variation in muscle mitochondrial content- Prof. Christopher Moyes
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33 min
35. Muscle mitochondrial function and biogenesis with aging- Dr. Russell Hepple
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23 min
36. The mitochondrial pathway in apoptosis- Prof. Douglas Green
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40 min
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38 min
38. Mitochondrial disorders and neurodegeneration- Prof. Anthony Schapira
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43 min
39. Respiration, reactive oxygen species and uncoupling proteins- Prof. Martin Brand
Printable Handouts
Navigable Slide Index
- Introduction
- Outline of presentation
- Role of mitochondria in muscle contraction
- ATP use in skeletal muscle
- Aerobic skills and mitochondrial oxidative capacity
- Mitochondrial content predicts muscle fatigue
- Mitochondrial capacity and muscle capacity
- Mitochondrial content increases with muscle use
- Capillary surface area
- Skeletal muscle contractile performance and aging
- Whole body aerobic capacity declines with aging
- Muscle mass declines with aging
- Functional deficits in aged skeletal muscle
- Pump-perfused rat hind limb model
- Mass-specific muscle oxygen declines with age
- Effect of aging on mitochondrial oxidative capacity
- Oxidative capacity of muscle declines with aging
- Structural capacity for oxygen delivery and aging
- Reductions in muscle aerobic function with aging
- Mitochondrial oxidative capacity in sarcopenia
- Mitochondrial dysfunction in aged muscle
- Mitochondria and ROS production
- Mitochondrial ROS production and aging
- Impaired coupling
- Oxygen cost of muscle contractions and aging
- Decline in some mitochondrial enzyme activities
- Oxidative capacity per mitochondrion and aging
- Changes in mitochondrial proetin abundance
- Mechanisms of mitochondrial dysfunction in aging
- Factors contributing to mitochondrial dysfunction
- Aging and mtDNA damage (1)
- Aging and mtDNA damage (2)
- Mitochondrial enzymes and oxidative damage (1)
- Mitochondrial enzymes and oxidative damage (2)
- Mitochondrial protein degradation and aging
- Mitochondrial protein synthesis rate and aging
- Mitochondrial biogenesis and aging
- Declines in ETC gene expression (1)
- Declines in ETC gene expression (2)
- Why does mitochondrial biogenesis decline?
- Summary
Topics Covered
- Role of mitochondria in muscle performance
- Changes in skeletal muscle contractile function with aging
- Effect of aging on mitochondrial oxidative capacity and its consequences
- Mitochondrial dysfunction in aged muscle
- Mechanisms contributing to mitochondrial dysfunction in aged muscles
Talk Citation
Hepple, R. (2007, October 1). Muscle mitochondrial function and biogenesis with aging [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 11, 2025, from https://doi.org/10.69645/TZVC7462.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Russell Hepple has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
