• Cellular Mechanisms of Mitochondrial Biogenesis in Health
• 23 min
  1. Nuclear control of electron transport chain gene expression

  • Dr. Glenn C. Rowe
• 48 min
  2. Regulation of mitochondrial biogenesis by transcriptional coactivators and estrogen-related receptor alpha

  • Dr. Anastasia Kralli
• 17 min
  3. Protein import into mitochondria

  • Dr. Trevor Lithgow
• 39 min
  4. Mitochondrial phospholipid synthesis and incorporation

  • Prof. Grant Hatch
• 23 min
  5. Mitochondrial DNA replication and transcription

  • Prof. Julio Montoya
• 37 min
  6. Mitochondrial production of reactive oxygen species 1

  • Prof. Martin Brand
• 22 min
  7. Mitochondrial production of reactive oxygen species 2

  • Prof. Martin Brand
• 35 min
  8. Mitophagy - the degradation of dysfunctional organelles

  • Dr. Anna Vainshtein
• Mitochondrial Biogenesis in Physiological Conditions
• 21 min
  9. Thyroid hormone and mitochondrial biogenesis

  • Dr. Joachim Weitzel
• 28 min
  10. Exercise-induced mitochondrial biogenesis in muscle 1

  • Prof. David Hood
• 37 min
  11. Exercise-induced mitochondrial biogenesis in muscle 2

  • Prof. David Hood
• Mitochondrial Biogenesis in Aging and Disease
• 33 min
  12. Mitochondrial diseases: an update

  • Dr. Ayesha Saleem
• 59 min
  13. Exercise and nutrition in mitochondrial disorders

  • Prof. Mark Tarnopolsky
• 42 min
  14. Mitochondrial disorders and neurodegeneration

  • Dr. Jan-Willem Taanman
• 33 min
  15. Reprogramming oxidative phosphorylation in cancer

  • Prof. José Cuezva
• 44 min
  16. Possible roles of mitochondrial biogenesis in aging

  • Dr. Aubrey de Grey
• 31 min
  17. Mitochondria in reproduction and fertility: mitochondria and gametes 1

  • Prof. Pascale May Panloup
• 30 min
  18. Mitochondria in reproduction and fertility: mitochondria and embryo 2

  • Prof. Pascale May Panloup
• 35 min
  19. Mitochondrial morphology and ultrastructure in skeletal muscle

  • Prof. Martin Picard
• 19 min
  20. Improving mitochondrial phenotypes with pharmaceuticals

  • Prof. Christopher Perry
• Mitochondria, Cell Signaling and Apoptosis
• 42 min
  21. Mitochondrial permeability transition

  • Prof. John Lemasters
• 47 min
  22. Pathways of apoptosis in muscle 1

  • Prof. Stephen E. Alway
• 42 min
  23. Pathways of apoptosis in muscle 2

  • Prof. Stephen E. Alway
• 21 min
  24. Controlling mitochondrial reactive oxygen species production for cell signaling 1

  • Dr. Ryan J. Mailloux
• 32 min
  25. Controlling mitochondrial reactive oxygen species production for cell signaling 2

  • Dr. Ryan J. Mailloux
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  26. Reactive oxygen species and myocardial apoptosis

  • Dr. Zhi-Qing Zhao
• 34 min
  27. Mitochondrial biogenesis as a result of exercise

  • Dr. Darrell Neufer
• 30 min
  28. Mechanisms of mitochondrial fusion and fission

  • Dr. Luca Scorrano
• 30 min
  29. Mitochondrial heterogeneity in cells

  • Dr. Tony Collins
• 40 min
  30. Mitochondrial diseases: an update

  • Prof. Salvatore DiMauro
• 41 min
  31. Calcium signaling and mitochondrial function

  • Prof. David Nicholls
• 35 min
  32. Mitochondrial biogenesis during gametogenesis and embryonic development

  • Prof. Pascal Reynier
• 33 min
  33. Mitochondrial complex assembly

  • Dr. Leo Nijtmans
• 33 min
  34. Evolutionary and developmental variation in muscle mitochondrial content

  • Prof. Christopher Moyes
• 33 min
  35. Muscle mitochondrial function and biogenesis with aging

  • Dr. Russell Hepple
• 23 min
  36. The mitochondrial pathway in apoptosis

  • Prof. Douglas Green
• 40 min
  37. Nuclear control of respiratory chain expression by transcriptional activators and coactivators

  • Prof. Richard Scarpulla
• 38 min
  38. Mitochondrial disorders and neurodegeneration

  • Prof. Anthony Schapira
• 43 min
  39. Respiration, reactive oxygen species and uncoupling proteins

  • Prof. Martin Brand

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The spectrum of mitochondrial diseases
3. Mitochondrial metabolic pathway
4. Human mtDNA
5. Maternal inheritance of mtDNA I
6. Maternal inheritance of mtDNA II
7. Classic mtDNA diseases
8. MtDNA mutations and disease - I
9. Patient with CPEO
10. Muscle biopsy from patient with CEPO
11. Histochemical staining: CEPO patient biopsy
12. EM of muscle biopsy from patient with CEPO
13. MtDNA mutations I
14. MtDNA mutations II
15. Deletion map of patients with CEPO
16. Progressive and external opthalmoplega
17. MtDNA mutations and disease - II
18. MELAS
19. Brain scan from a patient with MELAS
20. MELAS
21. tRNA Leu (UUR)
22. Protein coding mtDNA mutations
23. Common human mtDNA mutations
24. MtDNA mutations: epidemiology
25. Nuclear mutations of respiratory chain mutations
26. Nuclear gene encoded subunits
27. Components of respiratory chain complexes
28. Nuclear gene mutations of mitochondrial protein
29. Factors controlling oxidative phosphrylation
30. Mt proteins indirectly related to oxidative phos
31. Defects of mitochondrial maintenance
32. Southern blot showing depletion of mtDNA
33. Fatal mtDNA depletion syndrome
34. MtDNA depletion
35. POLG mutations - AuD PEO +/- parkinsonism
36. POLG mutations and PD
37. POLG mutations
38. POLG mutations - Alpers syndrome
39. POLG mutations
40. POLG and ageing
41. Neurodegenerative diseases - PD
42. Aetiology of Parkinson's disease
43. Complex I, GSH and Fe in neurodegeneration
44. Complex I activity in PD substantia nigra
45. Environmental influences on PD causation
46. Environmental influences on PD causation II
47. Network of PD pathogenesis
48. Inherited parkinsonism
49. Mitochondrial dysfunction and park genes
50. Genetic influence on mitochondrial function
51. Neurodegenerative diseases - HD
52. Huntington's disease I
53. Huntington's disease II
54. CAG repeat phenotype-genotype correlation in HD
55. R62 transgenic mouse model
56. Neurodegenerative diseases - FRDA
57. Friedreich's Ataxia: clinical features
58. FA GENE - 1
59. FRATAXIN
60. FRDA: genotype-phenotype
61. Mitochondrial function in cardiac muscle
62. FRDA in vivo biochemical study showing defect
63. GAA repeat genotype-phenotype correlation
64. Endogenous and exogenous toxins
65. Mitochondrial toxins
66. The spectrum of mitochondrial diseases

Topics Covered

• Spectrum of mitochondrial diseases
• Mitochondrial metabolic pathway
• MtDNA mutations and disease
• Pathological features
• MELAS
• Genetic epidemiology of mtDNA mutations
• Structural components of respiratory chain complexes
• Mitochondrial DNA metabolism
• Mitochondrial proteins and oxidative phosphorylation
• Fatal mtDNA depletion syndrome
• POLG mutations
• Environmental influences on PD causation
• PARK genes
• Huntington's disease and mtDNA mutations
• Genetic basis of Friedreich's ataxia
• Mitochondrial toxins

Links

Series:

• Mitochondrial Biogenesis
• Neurodegenerative Diseases

Categories:

• Cell Biology
• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on July 30, 2019

Financial Disclosures

• Prof. Anthony Schapira has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.