• Cellular Mechanisms of Mitochondrial Biogenesis in Health
• 23 min
  1. Nuclear control of electron transport chain gene expression

  • Dr. Glenn C. Rowe
• 48 min
  2. Regulation of mitochondrial biogenesis by transcriptional coactivators and estrogen-related receptor alpha

  • Dr. Anastasia Kralli
• 17 min
  3. Protein import into mitochondria

  • Dr. Trevor Lithgow
• 39 min
  4. Mitochondrial phospholipid synthesis and incorporation

  • Prof. Grant Hatch
• 23 min
  5. Mitochondrial DNA replication and transcription

  • Prof. Julio Montoya
• 37 min
  6. Mitochondrial production of reactive oxygen species 1

  • Prof. Martin Brand
• 22 min
  7. Mitochondrial production of reactive oxygen species 2

  • Prof. Martin Brand
• 35 min
  8. Mitophagy - the degradation of dysfunctional organelles

  • Dr. Anna Vainshtein
• Mitochondrial Biogenesis in Physiological Conditions
• 21 min
  9. Thyroid hormone and mitochondrial biogenesis

  • Dr. Joachim Weitzel
• 28 min
  10. Exercise-induced mitochondrial biogenesis in muscle 1

  • Prof. David Hood
• 37 min
  11. Exercise-induced mitochondrial biogenesis in muscle 2

  • Prof. David Hood
• Mitochondrial Biogenesis in Aging and Disease
• 33 min
  12. Mitochondrial diseases: an update

  • Dr. Ayesha Saleem
• 59 min
  13. Exercise and nutrition in mitochondrial disorders

  • Prof. Mark Tarnopolsky
• 42 min
  14. Mitochondrial disorders and neurodegeneration

  • Dr. Jan-Willem Taanman
• 33 min
  15. Reprogramming oxidative phosphorylation in cancer

  • Prof. José Cuezva
• 44 min
  16. Possible roles of mitochondrial biogenesis in aging

  • Dr. Aubrey de Grey
• 31 min
  17. Mitochondria in reproduction and fertility: mitochondria and gametes 1

  • Prof. Pascale May Panloup
• 30 min
  18. Mitochondria in reproduction and fertility: mitochondria and embryo 2

  • Prof. Pascale May Panloup
• 35 min
  19. Mitochondrial morphology and ultrastructure in skeletal muscle

  • Prof. Martin Picard
• 19 min
  20. Improving mitochondrial phenotypes with pharmaceuticals

  • Prof. Christopher Perry
• Mitochondria, Cell Signaling and Apoptosis
• 42 min
  21. Mitochondrial permeability transition

  • Prof. John Lemasters
• 47 min
  22. Pathways of apoptosis in muscle 1

  • Prof. Stephen E. Alway
• 42 min
  23. Pathways of apoptosis in muscle 2

  • Prof. Stephen E. Alway
• 21 min
  24. Controlling mitochondrial reactive oxygen species production for cell signaling 1

  • Dr. Ryan J. Mailloux
• 32 min
  25. Controlling mitochondrial reactive oxygen species production for cell signaling 2

  • Dr. Ryan J. Mailloux
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  26. Reactive oxygen species and myocardial apoptosis

  • Dr. Zhi-Qing Zhao
• 34 min
  27. Mitochondrial biogenesis as a result of exercise

  • Dr. Darrell Neufer
• 30 min
  28. Mechanisms of mitochondrial fusion and fission

  • Dr. Luca Scorrano
• 30 min
  29. Mitochondrial heterogeneity in cells

  • Dr. Tony Collins
• 40 min
  30. Mitochondrial diseases: an update

  • Prof. Salvatore DiMauro
• 41 min
  31. Calcium signaling and mitochondrial function

  • Prof. David Nicholls
• 35 min
  32. Mitochondrial biogenesis during gametogenesis and embryonic development

  • Prof. Pascal Reynier
• 33 min
  33. Mitochondrial complex assembly

  • Dr. Leo Nijtmans
• 33 min
  34. Evolutionary and developmental variation in muscle mitochondrial content

  • Prof. Christopher Moyes
• 33 min
  35. Muscle mitochondrial function and biogenesis with aging

  • Dr. Russell Hepple
• 23 min
  36. The mitochondrial pathway in apoptosis

  • Prof. Douglas Green
• 40 min
  37. Nuclear control of respiratory chain expression by transcriptional activators and coactivators

  • Prof. Richard Scarpulla
• 38 min
  38. Mitochondrial disorders and neurodegeneration

  • Prof. Anthony Schapira
• 43 min
  39. Respiration, reactive oxygen species and uncoupling proteins

  • Prof. Martin Brand

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Scheme of presentation
3. The mitochondria
4. Respiratory chain
5. Proteins of respiratory chain
6. Genetic classification (1)
7. Incidence of mitochondrial disease
8. Human mitochondrial DNA
9. Mitochondrial rules
10. Mitochondrial morbidity map - 2005
11. Genetic classification - defects of mtDNA
12. Typical age at onset of mtDNA-related diseases
13. Defects in protein-synthesis genes
14. mtDNA rearrangements
15. Point mutations in tRNA genes
16. MELAS
17. Muscle biopsy of MELAS patients
18. Defects in protein-coding genes
19. A patient's clinical history
20. The ND5 story
21. Muscle biopsy of ND5-mutant patient
22. Mutation in respiratory chain system
23. Typical age at onset of nDNA-related diseases
24. Coenzyme Q (CoQ10, ubiquinone)
25. CoQ10 in the mitochondrial respiratory chain
26. Coenzyme Q10 deficiency (1)
27. Muscle biopsy of patient with myopathy
28. Mutation in COQ2 - important step forward
29. CoQ10 biosynthetic pathway
30. Mutations in genes for respiratory chain subunits
31. Mutations in ancillary proteins
32. Mutations in genes encoding ancillary proteins
33. Defects in intergenomic signalling
34. Multiple deletions and depletion
35. nDNA mutations related to multiple deletions
36. mtDNA depletion
37. Gene defects in mtDNA depletion (1)
38. Mitochondrial nucleoside/nucleotide metabolism
39. Gene defects in mtDNA depletion (2)
40. Alpers syndrome
41. MPV17 gene
42. Navajo nation
43. Navajo neurohepatopathy (NNH)
44. Defect of the lipid milieu
45. Barth syndrome
46. Defects of mitochondrial motility
47. Opposite-polarity motors during transport
48. Mitochondrion on microtubule
49. Defects of mitochondrial motility/fission/fusion
50. Mitochondria?
51. Collaborators at CUMC

Topics Covered

• Mitochondrial functions
• Energy generation via oxidative metabolism
• The respiratory chain
• Mitochondrial DNA (mtDNA)
• Mitochondrial genetics
• A genetic classification of the mitochondrial diseases
• Diseases due to mutations in mtDNA
• mtDNA mutations impairing mitochondrial protein synthesis
• mtDNA mutations in specific protein-coding genes
• Diseases due to mutations in nuclear DNA (nDNA)
• Mutations in nuclear genes encoding subunits of respiratory chain complexes
• Mutations in nuclear genes encoding assembly proteins
• Defects of intergenomic communications
• Defects of the inner mitochondrial membrane lipid milieu

Links

Series:

• Mitochondrial Biogenesis

Categories:

• Cell Biology
• Clinical Practice

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. Salvatore DiMauro has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.