Tissue sampling and biopsy handling

This presentation will examine tissue sampling and biopsy handling with a focus on the fundamental principles and types of tissue sampling and biopsy procedures used for diagnosis and research, including needle, incisional, and excisional biopsies. We will discuss best practices for specimen collection, labeling, and fixation to ensure diagnostic accuracy and patient safety. The presentation will also address the prevention and recognition of artifacts, as well as the steps involved in laboratory processing and pathological examination of specimens. Finally, we will explore how pathologists integrate clinical information and ancillary tests to provide a comprehensive diagnosis. Tissue sampling and biopsy procedures are fundamental in diagnosis and research, forming the basis of pathology and laboratory medicine. Biopsies enable direct examination of cells and tissues, providing vital insight into disease and guiding patient care. Types include needle biopsies, fine needle aspiration, and core needle, used for accessible lesions, incisional biopsies, which remove a tissue portion from larger lesions and excisional biopsies, which remove the entire lesion for analysis. The choice of biopsy method depends on location, size, and clinical suspicion. The accuracy of laboratory diagnosis relies heavily on careful biopsy collection and labeling. Sterile techniques and proper instruments, such as scalpels for incisional or excisional biopsies, and specialized needles for