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- Principles in Bacterial Pathogenesis
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43 min
1. The molecular basis of bacterial pathogenicity: an overview- Prof. B. Brett Finlay
- Gram Negative Pathogens
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50 min
2. Deciphering shigella invasion of epithelial cells- Prof. Philippe Sansonetti
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43 min
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57 min
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34 min
5. Bordetella pertussis- Prof. Alison Weiss
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37 min
6. Salmonellae: molecular basis of infection- Prof. Samuel Miller
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43 min
7. The diversity of Escherichia coli infections- Prof. Michael Donnenberg
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18 min
8. Bacterial activation of epithelial signaling- Prof. Alice Prince
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48 min
9. Human pathogenic Yersinia species- Prof. James Bliska
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32 min
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46 min
11. Dental pathogens- Prof. Ann Progulske-Fox
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35 min
12. Haemophilus- Prof. Robert Munson
- Gram Positive Pathogens
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53 min
13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model- Prof. Pascale Cossart
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42 min
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48 min
15. Molecular pathogenesis and prevention of Staphylococcus aureus infections- Prof. Olaf Schneewind
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49 min
16. Streptococcus pyogenes disease and molecular pathogenesis- Prof. P. Patrick Cleary
- Host Responses
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29 min
17. Microbial recognition and the immune response- Dr. Dana Philpott
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40 min
18. Enteric pathogens-microbiota-host inter-kingdom chemical interactions- Prof. Vanessa Sperandio
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47 min
19. Toll-like receptor signalling during infection and inflammation- Prof. Luke O'Neill
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56 min
20. The human indigenous microbiota- Prof. David Relman
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53 min
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47 min
22. Role of neutrophils in acute lung injury and repair- Prof. Gregory Downey
- Preventatives and Therapeutics
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35 min
23. Antibiotics and antibiotic resistance- Prof. Gerry Wright
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36 min
24. Vaccines: a health insurance of the 21st century- Prof. Rino Rappuoli
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41 min
25. Biodefense vaccines- Prof. James Nataro
- Archived Lectures *These may not cover the latest advances in the field
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39 min
26. Vaccines in the modern world- Prof. Gordon Dougan
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39 min
27. Bacterial infection of epithelial signaling- Prof. Alice Prince
Printable Handouts
Navigable Slide Index
- Introduction
- Hp associated diseases
- Size variation of CagA
- The structure of the cagA gene
- VacA and CagA association
- CagA is present in a subset of strains
- cag is a pathogenicity island of Hp
- An hotspot for ISs within cag
- Type I and Type II strains of Hp
- Transition from commensal to pathogen
- cag genes are encoding a Type IV system
- Anatomy of the cag secretion system
- The structure of the Type IV core
- Type III and Type IV secretion systems
- CagA is translocated into the host cells
- CagA is Tyr-phosphorylated by the c-Src kinase
- Hp on the top of red blood cell
- In vitro delivery of CagA using red blood cells
- Ghosts formation after contacts with Hp
- The contacts with Hp cause polymerization
- Appendages induced upon contacts
- Hp in a biopsy of gastric mucosa
- Hp distributed on intercellular junctions
- ZO1 ectopic expression
- CagA targets the apical junctional complex
- The apical junctional complex structure
- CagA activity in polarized epithelial cells
- Cells expressing CT-CagA elongate
- Cells elongation
- Neuron-like movements
- Intercellular junction
- C-terminus: elongation properties
- CT-CagA and NT-CagA staining
- NT-CagA localizes to the AJC
- MDCK expressing NT-CagA
- Elongation and localization and something else?
- Shrinking process due to CagA action
- MDCK apical surface
- E-cadherin re-distribution
- Loss of cell polarity
- N and C-terminal portions do not alter polarity
- CagA induces loss of cell polarity
- MDCK expressing full-length CagA
- Only full-length CagA causes migration
- Anti-apoptotic effect after CagA expression
- CagA-dependent invadopodia formation
- Actin signal across BM
- Invasion process is protease-dependent
- MMP14 is expressed in CagA dependant manner
- Summary
- Possible mechanisms for CagA activity
- PAR1 interacts with CagA
- A stable MDCK line expressing CagA
- A new protein associated with CagA
- Tumor suppressors targeting
- Ways of bacteria to contaminate cells
- Collaborators
Topics Covered
- Helicobacter pylori: a chronic pathogen with lifelong association with the host
- The cag pathogenicity island encoding the Type IV secretion system and the CagA effector molecule
- CagA is translocated into the host cells and is tyrosine-phosphorylated by the c-Src kinase
- CagA affects the host cell terminal differentiation program
- CagA is associated with tumorigenic conversion acting simultaneously on two major pathways
Links
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Talk Citation
Covacci, A. (2010, July 15). From CagA to CagA: the metamorphoses of the Helicobacter pylori's cytotoxin-associated gene A into the cancer-associated gene A [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/CWVL7561.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Antonello Covacci has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
From CagA to CagA: the metamorphoses of the Helicobacter pylori's cytotoxin-associated gene A into the cancer-associated gene A
A selection of talks on Microbiology
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