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Printable Handouts
Navigable Slide Index
- Introduction
- Pharmacogenetics
- Pharmacogenomics
- Pharmacogenetics: brief history
- Specific examples to be considered
- Debrisoquine (CYP2D6) polymorphism
- Debrisoquine polymorphism: studies on phenotype
- Cytochromes P450
- Molecular basis of CYP2D6 polymorphism
- Poor metabolism and CYP2D6 polymorphisms
- Copy number variants in CYP2D6
- Number of CYP2D6 genes and nortryptiline
- Tamoxifen and CYP2D6
- CYP2D6 and codeine
- Ultrarapid metabolizers and codeine
- CYP2C9
- Functional effect of CYP2C9 alleles
- Warfarin
- Vitamin K cycle
- CYP2C9 genotypes and warfarin
- Warfarin dose requirement
- Vitamin K epoxide reductase
- VKORC1 polymorphisms (1)
- VKORC1 polymorphisms (2)
- CYP2C9/VKORC1 genotype warfarin dose
- Warfarin and pharmacogenetics
- Association study on warfarin dose requirement
- Methyltransferases
- Thiopurine S-methyltransferase (TPMT)
- TPMT polymorphism (1)
- TPMT polymorphism (2)
- Idiosyncratic adverse drug reactions
- Simvastatin myopathy
- Flucloxacillin-induced liver injury
- Summary
- References
Topics Covered
- Definition and history
- CYP2D6 polymorphism
- Pharmacogenetics of warfarin
- Thiopurine methyltransferase
- Genetics susceptibility to adverse drug reactions
Links
Series:
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Talk Citation
Daly, A. (2009, December 28). Pharmacogenetics [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 30, 2023, from https://hstalks.com/bs/1581/.Export Citation (RIS)
Publication History
Financial Disclosures
- Professor Ann Daly has no commercial/financial relationships to disclose.