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1. Introduction
2. Diversity of life
3. Human evolution (1)
4. Human specific adaptation
5. Understanding adaptaion through evolution
6. Artificial selection creates new breeds
7. Natural selection
8. Positive and negative selection
9. DNA sequences for detecting positive selection
10. The phylogeny tree
11. Nonsynonymous and synonymous mutations
12. Nonsynonymous/synonymous rate ratio
13. Positive selection of the MHC molecule
14. Application of NSDS ratio at genome wide scale
15. Positive selection in the immune system
16. Categorizing by tissue of maximal expression
17. Sperm competition
18. Evidence of sperm competition in primates
19. Human evolution (2)
20. Mutations in the human lineage
21. Significant genes subjected to positive selection
22. Population genetic data
23. McDonald-Kreitman test
24. Human genome: negative and positive selection
25. Selection coefficients
26. Selection sweeps
27. Escape by recombination
28. Selection sweeps pattern in the genome
29. Human genomic variation (HapMap) - Chr. 2
30. Lactose intolerance
31. Lactose intolerance in different populations
32. DNA variance and lactose intolerance
33. Lactase evolution
34. Genome differentiation among populations
35. Duffy
36. Selection of the CCR5 locus
37. FOXP2 and evolution of speech
38. Positive selection at the FOXP2 gene (1)
39. Frequency spectrum
40. Positive selection at the FOXP2 gene (2)
41. Body weight and brain size relationship
42. Microcephaly
43. The ASPM gene
44. Evolution of the ASPM gene
45. Microcephalin
46. Difficulties in detecting adaptations
47. Summary

Topics Covered

• Darwin, adaptation and natural selection
• Genome-wide analyses of natural selection in humans using comparative data
• Genome-wide analyses using population genetic data
• Individual genes potentially related to specific adaptations in humans
• Adaptionism in human molecular evolution

Links

Series:

• Introduction to Human Genetics

Categories:

• Genetics & Epigenetics

Talk Citation

Publication History

• Published on December 28, 2009

Financial Disclosures

• Prof. Rasmus Nielsen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.