• Basic Concepts
• 19 min
  1. Molecular structure of the human genome

  • Prof. Jonathan Wolfe
• 31 min
  2. Introduction to mutation and disease

  • Prof. Jonathan Wolfe
• 26 min
  3. Introduction to genetic diseases

  • Prof. Jonathan Wolfe
• 26 min
  4. Historical introduction to human diversity I

  • Prof. Dallas Swallow
• 28 min
  5. Historical introduction to human diversity II

  • Prof. Dallas Swallow
• 23 min
  6. Introduction to cytogenetics 1

  • Dr. Sioban SenGupta
• 15 min
  7. Introduction to cytogenetics 2

  • Dr. Sioban SenGupta
• 16 min
  8. Introduction to cytogenetics 3

  • Dr. Sioban SenGupta
• 42 min
  9. The Y-chromosome

  • Prof. Mark Jobling
• 42 min
  10. Mitochondrial DNA, molecular genetics and human mitochondrial diseases

  • Prof. Immo Scheffler
• 66 min
  11. Mechanisms of DNA repair by recombination

  • Prof. James Haber
• 26 min
  12. Techniques utilized in molecular genetics

  • Dr. Cecil Lewis
• 36 min
  13. Genome mapping

  • Dr. Simon Gregory
• 35 min
  14. Copy number variation

  • Dr. Ömer Gökçümen
• Genetics and Disease
• 45 min
  15. Genetic association studies

  • Prof. David Balding
• 42 min
  16. Quantitative genetics and multifactorial inheritance

  • Dr. Lara Bauman
• Human Evolutionary Genetics
• 34 min
  17. Population genetics

  • Dr. Murray P. Cox
• 59 min
  18. Inference on human history through DNA

  • Prof. Guido Barbujani
• 37 min
  19. Human adaptation

  • Prof. Rasmus Nielsen
• Specialized Topics
• 44 min
  20. Accessing and using ENCODE data

  • Prof. Peggy Farnham
• 44 min
  21. Pharmacogenetics

  • Prof. Ann Daly
• 33 min
  22. Genetics in forensics

  • Dr. Angel Carracedo
• 29 min
  23. The development and evolution of human gene therapy

  • Prof. Theodore Friedmann
• 33 min
  24. Next generation sequencing technologies

  • Dr. Krishna Veeramah

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Genome mapping (1)
3. Cytogenetic mapping (1)
4. Why study chromosomal aberrations?
5. Cytogenetic mapping (2)
6. Basic chromosome structure
7. G-banding: nomenclature & resolution
8. Cytogenetic mapping (3)
9. Molecular cytogenetic techniques
10. Fluorescence in situ hybridization (1)
11. FISH
12. DNA \ chromatin fiber-FISH "Molecular combing"
13. Comparative genomic hybridization (CGH)
14. Resolution of cytological techniques
15. Resolution of microarrays
16. Genetic mapping
17. Genes and disease
18. Genetic disease
19. Monogenic vs. complex disease gene
20. Approaches to identify disease genes
21. Linkage
22. Genetic markers and linkage?
23. Genetic linkage
24. Linked marker
25. Unlinked marker
26. Genome-wide linkage analyses
27. Genome mapping (2)
28. The human genome in context
29. The human genome project (1)
30. Human genome project ethos
31. Human genome mapping and sequencing
32. Hierarchical strategy
33. Mapping strategy
34. Milestones in the human genome project
35. The human genome project (2)
36. Comparative mapping
37. What is comparative mapping?
38. Comparative sequence analysis
39. Selection of species for DNA comparisons
40. Homology, Orthology, paralogy
41. Comparative mapping - mouse
42. Physical mapping strategy
43. Comparative mapping - mouse and human
44. Comparative sequence alignment
45. Sequencing the next generation
46. Acknowledgements

Topics Covered

• Cytogenetic mapping
• The purpose, approaches and applications in cytogenetic analysis
• Genetic mapping
• Approaches and methods for linkage analysis
• Genome mapping
• The evolution of mapping approaches
• The human genome project
• Comparative mapping
• Approaches and applications in comparative organisms

Links

Series:

• Introduction to Human Genetics

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on December 28, 2009
• Archived on September 8, 2024

Financial Disclosures

• Dr. Simon Gregory has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.