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Printable Handouts
Navigable Slide Index
- Introduction
- Electrophoresis: a powerful technique in genetics
- Electrophoretic mobility
- Mobility of two different amino-acids
- Harry Harris (1919-1994)
- Specific detection methods
- Mutation in phosphoglucomutase 1 (PGM1)
- Detecting size differences by electrophoresis
- Subtle changes - isoelectric focussing
- Protein polymorphism
- DNA polymorphism and electrophoresis
- Detection of size and conformational differences
- Detection of different number of tandem repeats
- Genotype and phenotype
- Crosses in the ABO blood group system
- Difficulties in interpreting the correct genotype
- Epistasis
- Multiple molecular forms or isozymes/forms
- Many proteins are encoded by multiple genes
- Subunits of phosphorylase kinase
- Multimeric proteins
- Subunits of lactate dehydrogenase
- Electrophoresis of samples from three people
- Distinguishing multiple genes from multiple alleles
- Analysis of enzyme polymorphism and isozyme
- Human genome sequence HapMap
- Functional implications of genetic variation
Topics Covered
- Electrophoresis
- Electrophoretic mobility
- Amino acids
- Specific detection methods
- Detecting protein size differences
- Ioselectric focusing
- Protein polymorphism
- DNA polymorphism and electrophoresis
- Tandem repeats
- Genotype and phenotype
- Epistasis
- Isozymes
- Many proteins are encoded by multiple genes
- Multimeric proteins
- How do we know that a protein is encoded by multiple genes/alleles?
- HapMap
- Functional implications of genetic variation
Talk Citation
Swallow, D. (2009, December 28). Historical introduction to human diversity II [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 12, 2024, from https://doi.org/10.69645/VCCK9548.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Dallas Swallow has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.