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Biomedical Basics

Cell senescence and ageing

  • Created by Henry Stewart Talks
Published on November 30, 2025   4 min

A selection of talks on Cancer

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The topic of Cell Senescence and Aging will be explored through the basic mechanisms of cellular aging, focusing on how telomere shortening and DNA damage drive cells into senescence. We will discuss how senescent cells, through changes like the senescence-associated secretory phenotype (SASP), disrupt tissue function and contribute to chronic inflammation and age-related diseases. The dual role of senescence—as both a tumor-suppressing process and a contributor to disease—will be examined. Finally, we will consider emerging approaches, such as senolytic therapies, aimed at targeting senescent cells to promote healthy aging.. Aging is a universal process marked by a gradual loss of physiological integrity and rising vulnerability to disease and death. Rather than a single cause, aging results from accumulated cellular and molecular damage. Senescence, where cells cease dividing and show distinct biochemical changes, is central to aging and disease. This lecture will explore the mechanisms of cellular aging, the role of telomeres, DNA damage, and how these contribute to tissue dysfunction and disease. To understand cell senescence, we examine the key drivers of cellular aging. Telomere shortening is a major factor—progressive loss of protective DNA-protein structures at chromosome ends. Each DNA replication round causes telomere erosion, leading to critically short telomeres seen as DNA damage, triggering permanent cell cycle arrest.

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