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- View the Talks
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37 min
1. Copy number variation- Prof. Steve Scherer
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17 min
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32 min
3. CNVs in human genomes- Prof. Chris Ponting
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32 min
4. Gene copy number variation in human and primate evolution- Prof. James Sikela
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64 min
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44 min
6. CNVs and clinical diagnosis- Dr. Brynn Levy
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43 min
7. Quantitative CNV testing in molecular diagnostics- Prof. Dimitri J. Stavropoulos
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33 min
8. Mendelian CNV mutations- Prof. Joris Vermeesch
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40 min
9. Copy number variation in neuropsychiatric disorders- Dr. Christian Marshall
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41 min
10. Copy number variation in association studies of human disease- Dr. Steven McCarroll
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21 min
11. Ethical considerations in dealing with CNV information- Dr. Holly Tabor
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38 min
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31 min
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31 min
- Archived Lectures *These may not cover the latest advances in the field
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26 min
15. Population genetics of structural variation- Dr. Don Conrad
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47 min
16. Databases for CNV in control and disease populations- Dr. Lars Feuk
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45 min
17. Copy number variation in mental retardation- Dr. Joris Veltman
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35 min
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34 min
19. Structural variants and susceptibility to common human disorders- Prof. Xavier Estivill
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40 min
20. Indels, CNVs and the spectrum of human genome variation- Prof. Samuel Levy
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36 min
21. Genome structure and expression- Prof. Alexandre Reymond
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39 min
22. Quantitative CNV testing in molecular diagnostics- Prof. Martin Somerville
Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Comparative genome hybridisation
- Conventional CGH
- Metaphase spread hybridised in CGH experiment
- CGH on microarrays
- 1Mb resolution array
- Array CGH
- Array CGH - example
- Conventional CGH vs. array CGH
- CNVs are present in normal individuals
- Assaying CNVs - BAC arrays
- Genome tilepath array (1)
- Genome tilepath array (2)
- Survey of CNVs in human population
- Survey of CNVs in human population - results
- Assaying CNVs - long oligo G-W arrays
- Whole-genome long oligo array
- Long oligo array vs. BAC array
- Resolution of the long oligo array
- Assaying CNVs - fosmid arrays
- Fosmid arrays
- BAC vs. fosmid array
- Redundant fosmid arrays
- Analysis of chromosome 22 breakpoint (1)
- Analysis of chromosome 22 breakpoint (2)
- Assaying CNVs - small insert library arrays
- Identification of chromosome specific markers
- BAC vs. fosmid vs. small-insert clones array
- Assaying CNVs - PCR amplicon arrays
- PCR amplicon arrays
- PCR amplicon arrays - example
- Assaying CNVs - tiling long oligo arrays
- Resolution of the 42M probe oligo array (1)
- Resolution of the 42M probe oligo array (2)
- CNV at 42M oligo-tiling resolution
- Complexity of known CNVs on chr1
- Perspectives
- Summary
- Acknowledgements
Topics Covered
- Array Comparative Hybridization (array-CGH) and measurement of copy number
- Development of array-CGH technology from convention CGH on metaphase chromosomes
- Initial use for identifying copy number changes in tumors
- Identification of normal copy number variation
- Increasing resolution of array-CGH reveals the scope, complexity and importance of normal copy number variation
Talk Citation
Carter, N. (2009, August 30). Array comparative genomic hybridization to characterize copy number variation in the human genome [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 26, 2024, from https://doi.org/10.69645/UOEI4279.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Nigel Carter has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Array comparative genomic hybridization to characterize copy number variation in the human genome
Published on August 30, 2009
17 min
A selection of talks on Genetics & Epigenetics
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