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Printable Handouts
Navigable Slide Index
- Introduction
- The alimentary tract
- Outline
- Taste vs. Flavor
- Relationship between the physicochemical properties of a compound and taste perception (1)
- Relationship between the physicochemical properties of a compound and taste perception (2)
- The taste buds are the sentries of the alimentary tract
- The taste bud (1)
- Taste bud cell types
- The taste bud (2)
- Atypical synapses in taste signaling
- Taste transduction
- Transduction pathways for the conventional taste stimuli
- Role of ENaC in taste signaling
- OTOP1 mediates sour taste
- T1R2 and T1R3: Sweet taste receptors
- T1R1/T1R3 heterodimer mediates L-amino acid taste
- T2R receptors mediate bitter taste
- Other proposed taste transduction mechanisms
- Anatomy of the ascending rodent gustatory system
- Anatomy of the ascending rodent gustatory system: Periphery
- Labeled-line model
- Across neuron pattern
- Labeled-line vs. across neuron pattern
- Calcium imaging in geniculate ganglion cells using a transgenic mouse line
- Many geniculate ganglion cells are narrowly tuned
- Some geniculate ganglion cells are less narrowly tuned, especially at higher concentrations
- Domains of taste function
- Sensory discriminative domain
- Important methodological features of tests to measure taste responsiveness
- Gustometer
- Two-response taste discrimination task
- ENaC’s role in rodent taste signaling (1)
- ENaC’s role in rodent taste signaling (2)
- Effect of amiloride on NaCl-evoked chorda tympani activity
- Effect of amiloride on NaCl and KCl detection
- Two classes of electrolyte-responsive fibers
- Amiloride adulteration disrupts NaCl–KCl discrimination
- Motivation/Affect domain
- Principle of the brief-access taste test
- Brief-access taste test
- Brief-access taste test: Application
- Chorda tympani responses to sweeteners
- Chorda tympani responses to sweeteners in T1R knockout mice (1)
- Chorda tympani responses to sweeteners in T1R knockout mice (2)
- Behavioral responses to sweeteners in T1R knockout mice
- Physiological domain
- Taste-induced cephalic phase insulin response
- Intraoral glucose (1.1 mL over 1.0 min) stimulates preabsorptive insulin release
- Only glucose was effective
- Domains of taste function are partially dissociable
- Supracollicular decerebrate rat preparation
- Proposed functional anatomy of the ascending rodent gustatory system (1)
- Supracollicular decerebrate rats display a cephalic-phase insulin response to glucose
- Proposed functional anatomy of the ascending rodent gustatory system (2)
- Taste domains
- Anatomical organization of the ascending gustatory system
- Functional roles of gustatory nerve branches
- Species differences in gustatory system organization
- Ventral forebrain and thalamocortical gustatory pathway
- Functional roles of gustatory pathways
- Central gustatory pathways in humans differ from rodents
- Summary
- Financial disclosures
Topics Covered
- The relationship between physicochemical properties of a compound and taste perception
- Taste buds
- Transduction pathways for taste stimuli
- Anatomy of the ascending rodent gustatory system
- Domains of taste function
- Testing taste function in rodent models
- Functional role of gustatory pathways
Talk Citation
Spector, A. (2026, January 28). The functional anatomy and physiology of the gustatory system [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved February 9, 2026, from https://doi.org/10.69645/RNOV4157.Export Citation (RIS)
Publication History
- Published on January 28, 2026
Financial Disclosures
- Alan Spector is on the Scientific Advisory Board of Gila Therapeutics (not in conflict with the content of this talk).
A selection of talks on Neuroscience
Transcript
Please wait while the transcript is being prepared...
0:00
Hello. My name is Alan Spector.
I'm a distinguished
research professor
in the department of psychology
and program in neuroscience at
the Florida State University.
I've been asked to give an
overview of the anatomy
and physiology of the
gustatory system,
and discuss its
functional organization.
I would like to thank HSTalks
for giving me the
opportunity to do so.
0:27
As you know, the alimentary
tract is one long tube.
It starts here,
and it ends here.
As solids and liquids are
placed in the mouth
and swallowed,
their contents
engage a variety of
sensory receptors which
send signals to the brain,
and indeed also trigger action
in the enteric nervous system.
0:52
Most of my professional
life has been focused here,
trying to understand what the
role of the gustatory system is
in the symphony of
signals arising
from the alimentary tract
and guiding behavior.
In this lecture, I will review
the basic hardware of
the gustatory system,
and relate it to the functional
properties of taste.
I would like to start
off by pointing out that
1:19
most people do not distinguish
between taste and flavor.
Flavor is the perceptual
integration of the taste,
smell, temperature, and
textural properties
of an oral stimulus.
Whereas taste is the
perceptual, behavioral,
and physiological
responses triggered by
signals arising specifically
from taste receptor cells.
This is why when
you have a cold,
you say food tastes differently,
but in reality, you should say
the food smells differently,
which is because
nasal congestion prevents
the volatile molecules
from reaching your
olfactory receptors.
Take the jellybean test.
Close your eyes and
pinch your nose,
and have your friend give you
a distinctly flavored jellybean.
See if you can
identify the flavor.
You will taste the
sweetness and the tartness
which is through the
gustatory system.
But you will be
unable to identify
the flavor like orange,
strawberry, vanilla,
or whatever, which
is based on smell.